PLLA IN COSMETICS_MR PAYAAM VOHRA-NIPER SAS NAGAR.pptx

PLLA IN COSMETICS

1. ROLE OF PLLA IN COSMETIC Submitted by Mr. Payaam Vohra M.S.(Pharm) Pharmacology and Toxicology NIPER SAS NAGAR

2. OBJECTIVES OF INCORPORATING PLLA IN COSMETICS 3 1 4 2 Collagen Stimulation Long Lasting Biocompatibility Rendon MI. Long-term aesthetic outcomes with injectable poly-l-lactic acid: observations and practical recommendations based on clinical experience over 5 years. J Cosmet Dermatol. 2012;11(2):93-100. Natural Appearance

3. MULTIFACETED ROLE OF PLLA Ao YJ, Yi Y, Wu GH. Application of PLLA (Poly-L-Lactic acid) for rejuvenation and reproduction of facial cutaneous tissue in aesthetics: A review. Medicine. 2024 Mar 15;103(11):e37506.

4. Poly-L-lactic acid (PLLA) is a biocompatible, re-absorbable, immunologically inert polymer that induces neocollagenesis through a subclinical inflammatory response Xu Q, Sun X, Yang W, Bai Y, Tan X. Comprehensive Systematic Review of Poly-L-lactic Acid in Facial Clinical Application. Aesthetic Plastic Surgery. 2024 Jun 20:1-21.

5. PLLA SPECIFICATIONS Vitrification Transformation temperature Melting point Dry weight loss Burning residue Heavy metal Total content Catalyst residue Monomer residue Solvent residue 60～65℃ 170～180℃ ≤0.5% ≤0.5% ≤10ppm ≤200ppm ≤1% ≤0.5% Coimbra DA, Amorim AGF. Ácido Poli-L-lactico na região medial dos braços. Surg Cosmet Dermatol. 2012;4(2):182-5. Unveiling the properties of PLA

6. Crystallinity — Most of the commercial L-PLA products are semi-crystalline polymers. It is desirable that PLA should have some crystalline content to benefit the quality of the finished product. Melting and glass transition temperature — They have a high melting point of 180 °C and a glass transition temperature ( Tg ) in the range of 55 - 60 °C. Strength — PLA is a high-strength and high-modulus thermoplastic with a good appearance. It has high stiffness and strength, comparable to polystyrene (PS) at room temperature. Processability — PLA can be easily processed using common techniques like injection molding, extrusion, blow molding, and 3D printing. This makes it versatile for a wide range of manufacturing processes. Energy consumption — Less energy is required in the production of PLA as compared to other plastics. They have better thermal processing. Nowag B, Schäfer D, Hengl T, Corduff N, Goldie K. Biostimulating fillers and induction of inflammatory pathways: A preclinical investigation of macrophage response to calcium hydroxylapatite and poly‐L lactic acid. Journal of Cosmetic Dermatology. 2024 Jan;23(1):99-106. PROPERTIES OF PLLA

7. Injection of PLLA particles into targeted areas Breakdown of PLLA particles by the body over time Triggering of natural wound healing response. Increased production of collagen. Improved skin plumpness, elasticity, and youthful appearance MECHANISM OF FILLERS OF PLLA Agrawal S, Gurjar P, Devadiga S, Pingale P, Rajput A. Biodegradable Polymers in Cosmetics and Cosmeceuticals. InHandbook of Biodegradable Polymers 2025 (pp. 651-682). Jenny Stanford Publishing.

8. MECHANISTIC OVERVIEW OF PLLA BASED BIOMATERIALS Seo SB, Kim SB, Yi KH. Effective improvement methods for striae distensae : A novel approach utilizing laser‐induced micro‐jet injectors With poly‐d, l‐lactic acid. Journal of Cosmetic Dermatology. 2024.

9. Pellets PLA pellets are small, cylindrical pieces of PLLA. They can be melted and molded into complex shapes. This makes it suitable for injection molding, extrusion, and thermoforming. PLLA Filament PLA filament is a thin strand of PLLA. It can be extruded into a strand that can be deposited layer by layer to create a PLLA Film PLA film is a thin sheet of PLLA. It is transparent, flexible, and acts as a barrier to moisture and gases. Thus it is commonly used for packaging. PLLA Sheet A PLA sheet is a thicker sheet of PLLA. It can be heated and molded into a variety of shapes and thus is commonly used for thermoforming and other applications. PLLA Fiber PLA fiber is a long, thin strand of PLLA. The soft, strong, and wrinkle-resistant properties of PLLA fibers make them suitable for use in textiles and other applications. PLLA Foam PLLA foam is a lightweight, porous material. Its lightweight, shock-absorbing insulating nature makes it suitable packaging .

10. TARGET MARKET

11. TOP LOCATIONS FOR PLLA SALES NORTH AMERICA EUROPE ASIA https://christinebyeresthetics.com/blogs/news/the-beginners-guide-to-poly-l-lactic-acid-skin-care

12. A PICTURE IS WORTH A THOUSAND WORDS

13. LIST OF PRODUCTS CONTAINING PLLA

14. Product Name Type Application Key Benefits Manufacturer Website Sculptra Injectable Filler Facial volume restoration, wrinkle reduction Long-lasting collagen stimulation, natural-looking results Galderma Sculptra Aesthetic AestheFill Injectable Filler Facial contouring, anti-aging Gradual volumizing, enhances skin texture Korea Filler Experts AestheFill Rejuran Injectable Solution Skin rejuvenation, texture improvement Promotes skin repair, youthful appearance HansBiomed Rejuran Caviplla Serum Anti-aging, skin plumping Non-invasive lifting, smoothes fine lines Art of Skin Care Caviplla HOP+ Serum, Mist Skin elasticity, firmness enhancement Supports collagen production, youthful glow Art of Skin Care HOP+ Lenisna Injectable Filler Facial volumizing, contouring Long-lasting volume, natural results Korea Filler Experts Lenisna Bellafill Injectable Filler Wrinkle and acne scar treatment Immediate volume, sustained collagen growth Suneva Medical Bellafill Silhouette Soft Thread Lift Non-surgical facelift Lifts sagging tissues, stimulates collagen Sinclair Pharma Silhouette Soft PCL Cosmetics Skincare Products Anti-aging, skin repair Deep hydration, improves texture, supports collagen Poly Korea Co., Ltd PCL Cosmetics Sichuan Xinda PLLA Microspheres Injectable Microspheres Facial volumization, wrinkle reduction Gradual, sustained skin volume improvement Sichuan Xinda Biopharmaceutical Sichuan Xinda Biopharmaceutical Resomer ® Evonik Industries Anti- aeging,Facial volumizer Biodegradable polymers for injectables and topicals Evonik Industries EVONIK Kuraray PLGA Kuraray filler Wrinkle and acne scar treatment Biocompatible fillers and cosmetic applications Kuraray KURRARE PLLA IN COSMETIC PREPARATIONS

15. FUTURE SCOPE PERSONALIZED BEAUTY

16. THANKS!