Dr. Monika Madaan
Specialist
Dept. Of Obstetrics & Gynaecology
ESI Hospital
Manesar
PPH
Single most important cause of maternal
mortality worldwide.
Accounts for 34% of maternal deaths in
developing countries.
Definition
Any blood loss than has potential to
produce or produces hemodynamic
instability
Definition
Blood loss > 500 ml after delivery
Primary : Loss within 1
st
24 hours after
delivery
Secondary : 24 hours till 12 weeks postnatally
Minor : 500-1000 ml
Moderate : 1000-2000 ml
Severe : > 2000 ml
PREDICTION AND PREVENTION
Identify pt. at risk
- Pl previa/accreta
-Anticoagulation Rx
-Coagulopathy
-Overdistended uterus
-Grand multiparity
-Abn labor pattern
-Chorioamnionitis
-Large myomas
-Previous history of PPH
PREDICTION AND PREVENTION
Active Management Of Third Stage Of Labor
(AMTSL): Should be offered routinely and
includes:
1.Administration of uterotonics soon after birth.
2.Delayed cord clamping.
3.Delivery of placenta by controlled cord
traction followed by uterine massage.
PPH Drill
Clear and logical sequence of steps
essential in the management of PPH.
CALL
FOR
HELP
Team Effort
•Skilled Obstetric Team
•Trained
Anaesthesiologist
•Clinical hematologist
•Supporting staff
Position flat
Keep the patient warm
Administer oxygen by mask ( @ 10-15 litres/
min)
Catheterize the patient for emptying bladder &
monitoring output
Fluid Replacement
RAPID WARMED infusion of fluids
Crystalloids : Fluids of choice until
compatible blood is arranged
1 ml of blood loss= 3 ml of crystalloids
Total volume of 3.5 litres of clear fluids
(upto 2 litres of crystalloids followed by 1.5
litres of warmed colloid )may be given while
awaiting compatible blood.
If hemorrhage is torrential
& fully cross-matched
blood still not available :
Uncrossmatched O
negative blood may be
given
FFP: 4 Units for every 6 Units of red cells OR
PT/ APTT > 1.5 X normal
(ie 12-15 ml/kg or total of 1 litres.)
Platelet Concentrate: if Platelet count< 50,000/
microlitre.
Cryoprecipitate: if fibrinogen < 1 g/ l.
Continuous vital monitoring.
Monitor adequacy of replacement with urine
output (0.5 ml/kg/hr) and CVP (4-8 cm water)
Main therapeutic goals are to maintain:
Haemoglobin > 8gm/dl
Platelet count > 75 × 10
9
/ l
Prothrombin < 1.5 × mean control
APTT < 1.5 × mean control
Fibrinogen > 1 gm/ l
Establish Etiology Simultaneously
4 T’s
Tone (abnormalities of uterine contraction) :
70 – 80%
Trauma (of the genital tract) : 20 %
Tissue (retained products of conception) : 10
%
Thrombin (abnormalities of coagulation) : 1 %
Contd…
Bimanual
Compression
If uterus is
relaxed :
massaging the
uterus will expel
any retained bits &
stimulate uterine
contractions
Administer Uterotonic Drugs
FIRST LINE
Oxytocin:
Start with 5 units slow iv or im.
Infusion of 20 units in 1 L@ 60 dr/min.
Continue same dose @ 40 dr/min until bleeding stops.
Maximum upto 3 L.
SECOND LINE
Ergometrine/ methyl ergometrine:
Dose: 0.2 mg im or slow iv
Repeat 0.2 mg after 15 min.
Maximum 5 doses (1 mg)
Syntometrine im
THIRD LINE
PGF 2α:
Dose: 0.25 mg im.
Can be repeated every 15 min.
Maximum upto 2 mg or 8 doses.
Misoprostol:
200-800 µg sublingually.
Do not exceed 800 µg
WHO GUIDELINES FOR MANAGEMENT OF PPH 2009
Initial Assembly
Condoms-2
Foley’s catheter-no.16
Saline with iv set
Speculum
Sponge holding
forceps
Procedure
Lithotomy position
Indwelling Foley’s
catheter.
Explore uterus, cervix and
vagina.
Inflate balloon with 100-
300 ml warm 0.9% Sodium
chloride until bleeding is
controlled (Positive
Tamponade Test).
Uterine Artery Embolization
Possible only if internal
artery ligation has not
been done and facility
for interventional
radiology available
Hysterectomy
Resort to hysterectomy “SOONER RATHER
THAN LATER”
High maternal morbidity
Timing and adequate replacement is of utmost
importance
Documentation and Debriefing
Important to record:
Sequence of events
Time and sequence of admn of
pharmacological agents, fluids, blood products
The time of surgical intervention
The condition of mother throughout .
Newer Developments
Tranexamic acid : 1 gm i.v slow. Can be
repeated after 30 min if bleeding continues./
Recombinant activated factor VII
(Novoseven): 90 µg/ kg . May be repeated
within 15-30 minutes. No clear consensus on
efficacy.
Carbetocin (oxytocin agonist) : 100 µg i.v or
i.m. Produces tetanic uterine contractions.
HAEMOSTASIS ALGORITHM
H – Ask for help
A – Assess and resuscitate
E – Establish etiology
M – Massage the uterus
O – Oxytocic administration
S – Shift to OT
T – Tissue n trauma to be excluded and proceed to
tamponade
A – Apply compression sutures
S – Systematic pelvic devascularisation
I – Interventional radiology
S – Subtotal or total hysterectomy
To Conclude, Management of
PPH Has Evolved From:
Panic
Panic
Hysterectomy
Pitocin
Prostaglandins
Happiness
ADDRESS
35 , Defence Enclave, Opp. Preet Vihar Petrol
Pump, Metro pillar no. 88, Vikas Marg , Delhi –
110092
CONTACT US
011-22414049, 42401339
WEBSITE :
www.lifecarecentre.in
www.drshardajain.com
www.lifecareivf.com
E-MAIL ID [email protected] [email protected] [email protected]
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