Ppi symposium muhsin

Ppi symposium muhsin

1. PPI: Short – term side effects:
Dr.Muhsin Abubakir
MBChB- FICMS-Int Med- Kurdistan Board GEH.
Consultant gastroenterologist & hepatologist

2. PPI:Short-tem(<12 weeks)side-effectsPPI:Short-tem(<12 weeks)side-effects
PPIs are generally well tolerated. PPIs are generally well tolerated.
The frequency of adverse effects associated with PPIs is similar to The frequency of adverse effects associated with PPIs is similar to
that of placebo, with an overall incidence of <5 percent.that of placebo, with an overall incidence of <5 percent.
The type/frequency of adverse effects are similar to those The type/frequency of adverse effects are similar to those
observed with histamine H2-receptor blockers. observed with histamine H2-receptor blockers.
The most common adverse effects are headache, diarrhea, The most common adverse effects are headache, diarrhea,
abdominal pain, nausea. abdominal pain, nausea.
Except for diarrhea, the adverse effects of PPIs do not appear to be Except for diarrhea, the adverse effects of PPIs do not appear to be
related to age, dosage, or duration of treatment.related to age, dosage, or duration of treatment.
 The diarrhea seems to be related to the profound acid The diarrhea seems to be related to the profound acid
suppression, which has been shown to alter the bacterial content suppression, which has been shown to alter the bacterial content
of the gut. of the gut.
The overall incidence of diarrhea is < 5 % &this effect appears to The overall incidence of diarrhea is < 5 % &this effect appears to
be dosage& age-related.be dosage& age-related.
PPI is aslo linked to MC.PPI is aslo linked to MC.

3. PPI:Short-tem(<12 weeks)side-effectsPPI:Short-tem(<12 weeks)side-effects
Short-term safety of the oldest agents, omeprazole &lansoprazole, Short-term safety of the oldest agents, omeprazole &lansoprazole,
has been well established.has been well established.
The safety profiles of the newer agents, rabeprazole& The safety profiles of the newer agents, rabeprazole&
pantoprazole, are similar to those of the older agents.pantoprazole, are similar to those of the older agents.
 PPIs are only contraindicated if the patient has a known history of PPIs are only contraindicated if the patient has a known history of
hypersensitivity to them.hypersensitivity to them.
They should be used with caution in patients with severe hepatic They should be used with caution in patients with severe hepatic
disease. disease.
Omeprazole is a pregnancy category C agent; the others are Omeprazole is a pregnancy category C agent; the others are
pregnancy category B medications.pregnancy category B medications.
PPIs are not recommended for use in breastfeeding mothersPPIs are not recommended for use in breastfeeding mothers