PPT.ppt dosage form notes for B.Pharm first year

dosage form

1. Pharmaceutical Dosage Forms
By
Himani Jaisinghani

2. What is Pharmaceutical Dosage Forms
A dosage form is a pharmaceutical preparation
consisting of drug and excipients to facilitate dosing,
administration, and delivery of the content to the drug
product.
The design, materials, manufacturing, and testing of all
dosage forms target drug product quality. A testing
protocol must consider not only the physical,
chemical, microbiological, and biological properties of
the dosage form as appropriate, but also the
administration route and desired dosing regimen.

3. List of official dosage forms
•Aerosols
•Capsules
•Creams
•Emulsions
•Films
•Foams
•Gases
•Gels
•Granules
•Gums
•Implants

4. List of official dosage forms
•Injections
•Inserts
•Shampoos
•Soaps
•Solutions
•Sprays
•Strips
•Suppositories

5. List of official dosage forms
•Suspensions
•Tablets
•Liquids
•Lotions
•Ointments
•Pastes
•Pills
•Powders

6. Dose Uniformity
Consistency in dosing for a patient or consumer requires
that the variation in the drug substance content of each
dosage unit be accurately controlled throughout the
manufactured batch or compounded lot of drug product.
Uniformity of dosage units typically is demonstrated by
one of two procedures: content uniformity or weight
variation.

7. Stability
Drug product stability involves the evaluation of
chemical stability, physical stability, and performance
over time.
For tablets, capsules, oral suspensions, and implants, in
vitro release test procedures such as dissolution and
disintegration provide a measure of continuing
consistency in performance over time.

8. Bioavailability
Bioavailability is influenced by factors such as the method of
manufacture or compounding, particle size, crystal form (polymorph)
of the drug substance, the properties of the excipients used to formulate
the dosage form, and physical changes as the drug product ages.
With proper justification, in vitro release testing (e.g., disintegration
and dissolution) may be used as a surrogate to demonstrate consistent
availability of the drug substance from the formulated dosage.

9. Dosage Form/ Drug Delivery
System by route of administration
Oral
Tablets
Capsules
Solutions
Syrups
Elixirs
Suspensions
Gels
Powders
Sublingual
Tablets
Lozenges
Parenteral
Solutions
Suspensions
Conjunctival
Contact lens inserts
Ointments

10. Dosage Form/ Drug Delivery
System by route of administration
Epicutaneous /
transdermal
Ointments
Creams
Infusion pumps
Pastes
Plasters
Powders
Aerosols
Lotions
Intraocular
Solutions
Suspensions
Intranasal
Solutions
Sprays
Inhalers
Ointments
Intrarespiratory
Aerosols

11. Dosage Form/ Drug Delivery
System by route of administration
Vaginal
Solutions
Ointments
Emulsion foams
Gels
Tablets
Inserts,
suppositories
Rectal
Solutions
Ointments
Suppositories
Urethral
Solutions
suppositories

12. Solid Dosage Forms
Powders and Granules
Capsules and Tablets

13. Powders and Granules
Powders
Blending Powders
Medicated Powders
Aerosolized Powders
Granules
Effervescent

14. Capsules
Hard Gelatin Capsules
Soft Gelatin Capsules

15. Hard Gelatin Capsules

16. Tablets
Compressed tablets
(C.T.)
Multiple Compressed
tablets (M.C.T.)
Sugar-Coated Tablets
(S.C.T.)
Film Coated Tablets
(F.C.T)
Gelatin Coated Tablets
Enteric Coated Tablets
(E.C.T.)
Buccal or Sublingual
Tablets
Chewable Tablets
Effervescent Tablets
Immediate release
Tablets (I.R.)
Instant
Disintegrating
/Dissolving Tablets
Extended release
Tablets (E.R.)
Vaginal Tablets

17. Compressed Tablets contains:
API
Diluents or filler
Binders or adhesives
Disintergrants
Lubricants
Miscellaneous adjuncts
Colorants and flavorants

18. Compressed tablets
Tablets
Multiple Compressed tablets Sugar-Coated Tablets Film Coated Tablets
Gelatin Coated Tablets Enteric Coated Tablets

19. Modified-Release Dosage Forms
and Drug Delivery Systems
Modified Release
Extended Release
Delayed Release
Repeat action
Targeted Release
Terminology of
extended release
Sustained Release (SR)
Sustained Action (SA)
Prolonged Action (PA)
Controlled Release (CR)
Extended Release (ER)
Timed Release (TR)
Long Acting (LA)

20. Nonoral Modified-Release Systems
Ocular
Parenteral Systems
Vaginal Inserts
Subdermal Implants

21. Semi-Solid Dosage Forms
Ointments
Creams
Gels
Pastes
Plasters

22. Transdermal Drug Delivery
Systems

23. Example Of transdermal Drug
delivery systems

24. Pharmaceutical Inserts
Suppositories

25. Liquid Dosage forms
Solutions
Disperse systems

26. Solutions
Oral Solutions
Otic Solutions
Ophthalmic Solutions
Topical Solutions
Spirits

27. Oral Liquid Dosage Forms
Oral solutions
Syrups
Elixirs
Tinctures

28. Example of Syrup
Antihistamine Syrup
1.Chlorpheniramine maleate 0.4g
2.Glycerin 25.0ml
3.Syrup base 83.0 ml
4.Sorbitol solution 283 ml
5.Sodium Bezoate 1.0 g
6.Alcohol 60.0 ml
7.Color and Flavor q.s.
8.Purified water to make 1000.0ml

29. Disperse Systems
Suspensions
Emulsions
Aerosols

30. Sterile Dosage Forms and
Delivery Systems
Parenterals
Biologicals
Ophthalmic solutions and
suspensions

31. Injection Types

32. Automatic injection
Medi-Jector:Needle Free

33. Thank
you