PPT SENYAWA KOMPLEKS_chemistry GROUP 3.pptx

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1. Complex Compound Mechanism Physical Inorganic Chemistry Lecturer : Lisnawaty Simatupang,M.Si

2. Group 3 Erianti Simbolon (4203131028) Maya Jenita Simatupang (4203331001) Mutiara Panca Putri Sinuhaji (4203131046) Rahma Safitri (4203332024) Vira Maharani (4202431018)

3. Preliminary Discussion Summary Of Journal Closing Table Of Content

4. PRELIMIARY

5. Complex compounds, often also called coordination compounds, are compounds formed by a central atom or ion with several molecular groups or ion groups through coordination covalent bonds. The molecular group or ion that is bound to the central ion is called a surrounding group or a ligand, while the number of coordination bonds between the central atom and the donor atom (of the ligand) is expressed by the coordination number ( Sugiarto and Retno , 2008). Apart from the attractive colors that occur in the formation of complex compounds, complex compounds are widely applied in various fields of human life, such as in the fields of health, pharmaceuticals, industry, and catalysts. Background

6. First Journal Journal tittle’s : Kinetic and mechanism formation reaction of complex compound Cu with di-n- buthildithiocarbamate ( dbdtc ) ligand Journal name’s :IOP Conference Series: Materials Science and Engineering Author : S. Haryani , C. Kurniawan , Kasmui Year : 2018 Number (Issue) : 1 (2) Pages : 1-5 DOI :10.1088/1757- 899X/349/1/012060 Identity Of Journal Second Journal

7. T hird Journal Identity Of Journal Fourth Journal Journal tittle’s : Application of Coordination Compounds with Transition Metal Ions in the Chemical Industry—A Review Journal name’s : Internasional Journal Molecular Sciences (MDPI) Author : Jacek Malinowski , Dominika Zych , Dagmara Jacewicz , Barbara Gawdzik ,and Joanna Drzez˙dz˙o Year : 2020 Number (Issue) : 21(1) Pages : 1-26 DOI : 10.3390/ijms21155443

8. Summary Of Journal

9. Journal 1 Synthesis of complex compound is one field of research which intensively studied. Metal- dithiocarbamate complexes find wide-ranging applications in nanomaterial and metal separation science, and have potential use as chemotherapeutic, pesticides, and as additives to lubricants. The synthesis of complex compounds is always related to the development of analytical procedures that always attract the attention of researchers. In developed countries research in the field of synthesis of complex compounds has been done intensively and can now be synthesized various complex compounds that are useful in various industries, however information on kinetics and mechanisms of reaction is still very less. Introduction

10. Purpose Based on the description of the above background then the problem to be solved in this research is to know how the kinetics equation of the reaction of the formation of complexes Cu with di- nbuthyldithiocarbamate . The first stage, at this stage will be synthesized ligand di-n- buthyldithiocarbamate according to procedures Taufan and co-worker that is from the reaction between di-n-butyl amin with karbondisulfida . Into the erlenmeyer flask placed on a large glass beaker filled with 5 mL of concentrated carbondisulfide was then added 6. 25 mL concentrated NH4OH, shaked gently. While continuously shaken, it was added dropwise in thick n- butylamin as much as 13. 75 mL. Once the pasta is formed, the paste continues to stir slowly until it becomes a crystal. The formed crystals are dried in a wind-blown way. The synthesis results were tested for their efficacy by thin layer chromatography TLC, and characterized by melting point determination, UV-VIS spectroscopy method and Infrared spectroscopy method. Methods

11. Results and Discussion The result of this research will be more useful if an effort is being done in reaction mechanism by chemical computation method for obtain intermediate, and for constant “k” in same stage, k1.k2. and compound complex constanta. The research and analyzes results show that reaction synthesis ligand DBDTC and complex compounds Cu-DBDTC. Optimum reaction condition of formation of complex compounds Cu with DBDTC at pH=3, [DBDTC] = 4.10-3 M, and the time of reaction 5 minutes. Based the analysis varian reaction of complex compounds at pH 3 and 4, diffrence significance at the other pH: 5; 5,5; 6; 6,5 ; 7; and 8. The various of mole with reactants comosition difference significance, those the time reaction for 5 and 6 minutes diffrence by significance with the other time, it is 3,4,8, and 10 minutes. The mechanism of formation of complex compounds Cu (DBDTC) 2 is :

12. Conclusion The conclusions obtained from this study are : (1) the synthesis results of Cu-DBDTC complex compounds according to the character of the compound. (2) the optimum conditions of complex shielding between Cu 2+ and Di-n- butyldithiocarbamate (DBDTC) were achieved at pH 6.5; [DBDTC] = 4 x 10 -3 M; reaction time 5 minutes; and the mole ratio of the metal: mol ligand is 1: 2. (3) he kinetic equation obtained is v = 0.917106 [Cu 2+ ] 0.87921[DBDTC]2.03021. (4) Mechanism of reaction of complex formation of Cu (DBDTC) 2 covering 2 stages. The first stage is formed [Cu (DBDTC)] + , then formed [Cu(DBDTC) 2 ] with possible geometry structure is square planar.

13. Journal 4 The use of complex compounds in processes employed in the broadly understood chemical industry is a very important aspect of the work of scientists around the world. Processes carried out on an industrial scale and conducted by scientists are enjoying the growing recognition of global corporations dealing in the production of various polymeric materials used in many aspects of our lives, • Wacker Process

14. • Sharpless System for Asymmetric Epoxidation of Olefins with Hydroperoxide with Dimeric Titanium Complex as a Catalytically Active Form Sharpless conducted research on the use of organometallic catalysts in the asymmetric epoxidation reaction

15. Journal 5

16. Targeted anticancer prodrugs that can be controllably activated are highly desired for personalized precision we report coumaplatin , an oxaliplatin-based and photocaged Pt(IV) prodrug, to realize nuclear accumulation along with “on- demand” activation. This prodrug is based on a Pt(IV) complex that can be efficiently photoactivated via water oxidation without the requirement of a reducing agent. Coumaplatin accumulates very efficiently in the nucleoli and upon photoactivation, this prodrug exhibits a level of photocytotoxicity up to two orders of magnitude higher than that of oxaliplatin.

17. Unexpectedly, this prodrug presents strikingly enhanced tumor penetration ability and utilizes a distinct action mode to overcome drug resistance, i.e., coumaplatin but not oxaliplatin induces cell senescence, p53 independent cell death, and immunogenic cell death along with T cell activation. Our findings not only provide a novel strategy for the rational design of controllably-activated and nucleolus-targeted Pt(IV) anticancer prodrugs but also demonstrate that accumulating conventional platinum drugs to the nucleus is a practical way to change its canonical mechanism of action and to achieve reduced resistance.

18. To the best of our knowledge, we have reported the first photocaged, water-oxidizing, and nucleolus-targeted Pt(IV) anticancer prodrug, coumaplatin (Figure 5). This prodrug remained stable in a reducing environment but could be controllably activated to oxaliplatin via exposure to low- intensity visible light. The prodrug utilized a unique photoactivation mechanism, i.e., water oxidation, to be photo-reduced without the requirement of a reducing agent. Coumaplatin possessed a stronger tumor penetration ability than oxaliplatin, making it even more powerful in killing cells in the necrotic regions of tumor spheroids. Owing to the nucleolus-accumulation ability, coumaplatin not only showed significantly increased photocytotoxicity but could also overcome drug-resistance through a distinct mechanism of action. The prodrug entered cells efficiently and accumulated well in the nucleolus. After “on-site” activation, coumaplatin was effectively reduced to oxaliplatin, leading to increased amounts of Pt in the genomic DNA.

19. Advantage and Disadvantage of Journal

20. Disadvantages First Journal Advantages The journal contains all proper journal formats such as abstract, introduction, materials and methodology, result and discussion, and also conclusion in easy-understanding language. When viewed from the completeness of the content of the material, this journal presents material related to the topic in a fairly complete and detailed manner. There are tables as well as mechanisms of formation of complex compounds so that it helps readers more easily understand the contents of the journal. There are no significant deficiencies, it's just that the references used are not too many and many reference years are not the latest publications.

21. Disadvantages Fourth Journal Advantages This journal has been well written and every mechanism provided by the author has information and explanations that are quite easy to understand as well as the use of language in the journal that can still be understood by readers The author is also very good at putting every mechanism in the journal and the picture of the mechanism is not messy The author also uses many references so that if the reader does not understand, he can read other references The weakness in journals is that they are not written in the usual journal format which contains introductions, theories, research methods, results and conclusions but only discusses the benefits of complex compounds in the chemical industry. do not understand whether the journal is the result of research from that author or not.

22. Closing

23. In the first journal explains the mechanism of complex compounds. Based on the kinetic data, and formed complex compounds estimation, the mechanism explaining by 2 stages. In the second journal explains the meaning of complex compounds. Complex compounds is a compound can be formed because some metals and ligands form coordination covalent bonds. In the fourth journal explain the use of complex compounds in processes employed in the broadly understood chemical industry is a very important aspect of the work of scientists around the world. Processes carried out on an industrial scale and conducted by scientists are enjoying the growing recognition of global corporations dealing in the production of various polymeric materials used in many aspects of our lives Conclusion