PREMENSTRUAL SYNDROME-Shatavari Churna THESIS.pptx

Evaluating the Efficacy of Shatavari Churna in Pittavrita Vyana Vayu: A Single-Arm Clinical Study w.r.t. Premenstrual Syndrome”
This presentation reports a clinical investigation into how the Ayurvedic herb Shatavari (Asparagus racemosus), administered as churna, affects PMS symptoms interpreted through the frame of Pittavrita Vyana Vayu. The study explores symptom relief, improvements in psychological and somatic parameters, and provides insight into Ayurveda-based management of PMS.

1. DISSERTATION PRESENTATION DR SAGAR D DHERANGE PG SCHOLAR DEPARTMENT OF STRIROGA & PRASUTITANTRA

2. A single arm Clinical study of shatavari churna in pittavrita vyana vayu w.s.r . To premenstrual syndrome GUIDED BY DR SMITA S CHODANKAR ASSOCIATE PROFESSOR DR T VISHALA PROFESSOR & HOD DEPT OF SRPT, YAC KODOLI

3. CONTENTS… Aims & Objectives Research Question Hypothesis Review of Literature Materials & Methods Observations Statistical Analysis Discussion Conclusion

4. AIMS & OBJECTIVES 4

5. AIMS To study the role of Shatavari Churna in Pitta Avrutta Vyana Vayu w.s.r . to PMS OBJECTIVES To reduce the signs & symptoms To assess improvement by parameters VAS. To study the etio -pathology of Pitta avrutta vyana vayu & premenstrual disorder in detail with classic ayurved & modern text To achieve the out-come of study in 120 days. vrutta Vyana Vayu w.s.r . to PMS

6. Primary research question In the age group of 15 to 30 year females does Shatavri Churna 3 grams orally with water twice a day has any role on Pitta avrutta Vyana Vayu w.s.r . to Premenstrual Syndrome?

7. HYPOTHESIS 7

8. Null Hypothesis – There is no any significant role of shatavari in pitta avrut vyana vayu w.s.r . to premenstrual syndrome.   Alternative Hypothesis – There is significant role of shatavari in pitta avrut vyana vayu w.s.r . to premenstrual syndrome

9. Review of Literature 9

10. DISEASE REVIEW 10

11. Pitta Avrut Vyana Vayu 11

12. SAMPRAPTI 12

13. Premenstrual syndrome is a P sycho N euro endocrine disorder U nknown etiology Seen in luteal phase of menstruation i.e. Just 7-10 days before menstruation which resolves after menstruation C haracterized by dramatic physical, mental, psychological, social & behavioral changes which alternatively reflect in her day to day activities DISEASE REVIEW 13

14. शीत कषाया मधुरा स्निग्धा वृष्या रसायनी । वात पित्त विबंधघनी वर्ण ओज बलवर्धनी ।। स्मृती मेधा मतिकरी पथ्या पुष्प प्रजाकरी ।भूत कल्मषशाप घनी शतवीर्या शतावरी ।। आर्तव या न पश्यन्ति पश्यन्ति विफल च या : ।अति प्रभूतमत्यल्प मति क्रांत मनागतं ।। अकर्मण्यम विस्त्रांसी किंजत मृतयश्च या ।दुर्बला अदृढ पुत्रांश्च कृशाश्च वपुषा अथ या।। प्रस्कन्दना विवर्ण श्च याशच प्रचुर मूर्तय ।स्पर्श च या विन्दन्ति याशचं स्यु शुष्कयोनय।। शतपुष्पां शतावरयो स्यातां तत्रामृत यथा ।पुमान प्यु प युंजानो यथोक्त अनुमृते गुणांन ।। का क शतपुष्पा शतावरी कल्प अध्याय 4 Rasa- Madhura Veerya-Sheeta Vipaka-Madhura Guna - Guru, Snigdha , Sheeta Doshaghnata-VataPittashamaka DRUG REVIEW 14

15. 1 ) Patient fulfilling diagnostic criteria of pitta avruta vyana vayu . 2) Patients are selected of age group between15-30year. 3) Regular menstruating females and whose periodic cycle is regular 2-6 days (25- 31 Day cycle) 4)Patient irrespective of marital status, obstetric status ,education ,occupation         1)Inclusion Criteria- 15

16. K/H/O mood disturbance because of any systemic disorder / any other psychiatric disorders Women with K/H/O severe systemic illnesses Women who taking oral contraceptives and hormone replacement therapy Premature ovarian failure Major gynaecological disorders Exclusion criteria: 16

17. Patients who are not following the appropriate guidelines of treatment Patient who don’t come for follow up. Patients want to quit from study at any moment Withdrawal Criteria : 17

18. Materials & Methods Total 100 Patients Clinically Diagnosed of PRE MENSTRUAL SYNDROME wERE selected randomly from OPD/IPD of SRPT DePT of our institute and collage camps. 18

19. OPD

20. IPD

21. COLLEGE CAMP

22. NURSING COLLEGE CAMP

23. Authentication & Standardization ashoka valkala Churna used for the clinical trial was obtained from genuine source. Authentification & standardization of the drug was done from renowed pharmaceutical & analytical laboratory.

24. CRITERIA OF ASSESSMENT Symptom Present (1) Absent(0) Sarvanga Daha Klama GatraVikshepa sanga Santapa Criteria Grade Symptoms Vedana No vedana   1 Mild vedana   2 Moderate vedana   3 Severe vedana Symptoms Present (1) Absent (0) Mood Swing     Anger     Depressed Mood     Lethargy     Sleep changes     Change in apetite     Breast Pain/Tenderness/Swelling     Sensation Of Bloating    

25. OBSERVATIONS 25

26. 26 GRAPH SHOWING DISTRIBUTION OF PATIENTS ACCORDING TO AGE

27. 27 GRAPH SHOWING DISTRIBUTION OF PATIENTS ACCORDING TO RELIGION

28. 28 GRAPH SHOWING DISTRIBUTION OF PATIENTS ACCORDING TO OCCUPATION

29. 29 GRAPH SHOWING DISTRIBUTION OF PATIENTS ACCORDING TO DEHA PRAKRITI

30. 30 GRAPH SHOWING DISTRIBUTION OF PATIENTS ACCORDING TO DIET

31. 31 GRAPH SHOWING DISTRIBUTION OF PATIENTS ACCORDING TO BMI

32. 32 PIE DIAGRAM SHOWING DISTRIBUTION OF PATIENTS ACCORDING TO MARITAL STATUS

33. 33 GRAPH DIAGRAM SHOWING DISTRIBUTION OF PATIENTS ACCORDING TO OBSTESTRIC STATUS

34. 34 GRAPH SHOWING DISTRIBUTION OF PATIENTS ACCORDING TO SOCIO-ECONOMIC CLASS

35. STATISTICAL ANALYSIS 35

36. 36 GRAPH SHOWING CHANGES IN MEAN AND MEDIAN VALUES OF SARVANGA DAHA

37. 37 GRAPH SHOWING CHANGES IN MEAN AND MEDIAN VALUES OF KLAMA

38. 38 GRAPH SHOWING CHANGES IN MEAN AND MEDIAN VALUES OF SANTAPA

39. 39 GRAPH SHOWING CHANGES IN MEAN AND MEDIAN VALUES OF VEDANA

40. 40 GRAPH SHOWING CHANGES IN MEAN AND MEDIAN VALUES OF MOOD SWINGS

41. 41 GRAPH SHOWING CHANGES IN MEAN AND MEDIAN VALUES OF ANGER

42. 42 GRAPH SHOWING CHANGES IN MEAN AND MEDIAN VALUES OF DEPRESSED MOOD

43. 43 GRAPH SHOWING CHANGES IN MEAN AND MEDIAN VALUES OF LETHARGY

44. 44 GRAPH SHOWING CHANGES IN MEAN AND MEDIAN VALUES OF SLEEP CHANGES

45. 45 GRAPH SHOWING CHANGES IN MEAN AND MEDIAN VALUES OF CHANGE IN APPETITE

46. 46 GRAPH SHOWING CHANGES IN MEAN AND MEDIAN VALUES OF BREAST PAIN

47. 47 GRAPH SHOWING CHANGES IN MEAN AND MEDIAN VALUES OF BLOATING SENSATION

48. 48 GRAPH SHOWING OVERALL EFFECT OF TREATMENT

49. Discussion 49

50. PROBABLE MODE OF ACTION OF SHATAVARI : RASA : Tikta : Tikta rasa by its Khara and Soshana properties, which is similar to asthi dhatu when used with kshira is asthi vriddhikara . (A. Hr. Su. 11/31) Madhura : Madhura rasa is vata shamaka and prithvi mahabhuta dominant. This helps in minimizing asthi kshaya .   GUNA: Guru : Guru guna is again prithivi mahabhoota dominant and hence can be thought to be acting at the level of all dhatu poshana . Snigdha : Tikta rasa along with Snigdha guna is again asthi vriddhi kara . (A. Hr. Su. 11/31) Both these properties are vata shamaka .   VIPAKA : Madhura vipaka acts by virtue of privthvi dominant mahabhoutik constitution .

51. PRABHAVA Shatavari Possesses Rasayana Prabhava . Rasayana promotes qualities of all dhatu . This is achieved by improving digestion and metabolism, leading to enriched nutritional status at the level of dhatus . Rasayana increases endurance and sustaining capacity of individuals by promoting deha bala . These all properties of Rasayana herbs delays aging phenomena . Anti oxidant, immunomodulating and adaptogenic effects of Shatavari are well known. The main mechanism of action of Shatavari as Rasayana is at the level of nutrition of Ahara rasa; promoting nutrition of all dhatus . Hence, Shatavari promotes asthi Poshana and prevents asthi kshaya in age by counteracting the vitiation of vata . Inhibiting the tissue depletion ( dhatukshaya ), maintaining the qualities of tissues ( Prashastha dhatus ), enhancing the strength ( bala ) and promoting digestion and metabolism. ( Jathargni and dhatvagni ).  

52. Conclusion 69 were totally cured Shatawari Choorna is Significantly Effective in PMS . No any adverse event seen during Study. 52

53. Thank You……. Dr Sagar D Dherange [phone] [email protected] 53