Preparation and Formulation of Cetrimide Cream

From this slideshow you can learn how to prepare and formulate Cetrimide cream in the laboratory.

1. Pharmaceutics II Laboratory Experiment Preparation & Formulation of Cetrimide Cream

2. RAFIA SULTANA (1269) - Group Leader MD.RAFIQUL ISLAM (1194) SHAIKAT KUMAR BARMAN ( 1164) HRIDOY KUMER DEY (1155) SADIA FIROZ (1136) SUNJIDA MALIHA (1129) Group :: B

3. What is cream ? Pharmaceutical creams are semisolid preparations containing one or more medicinal agents dissolved or dispersed in either a W/O emulsion or an O/W emulsion or in another type of water-washable base. Creams have a relatively soft, spreadable consistency; an example of a W/O cream is cold cream and an example of an O/W cream is hydrophilic ointment. Creams find primary application in topical skin products and in products used rectally and vaginally .

4. Properties of Cream: Absorption: Quickly absorbed by the skin Consistencies: Higher Greasiness: Less greasy Transparency: White Conc. of oil: Lower conc. of oil than ointment Spreading ability: High Stability on skin: Stay short time on surface Healing power: Fast.

5. Formula Ingredient Master formula (1000 g) Working formula (10 g) Cetrimide 3 g 0.003g Cetostearyl alcohol 50 g 0.5 g Liquid paraffin 500 ml 5 ml Distilled water 1000 ml 10 ml

6. Cetrimide Active ingredient of the medicated cream An antiseptic agent Mixture of different quaternary ammonium salts including CTAB Cetrimide bromide

7. Cetrimide

8. Uses of cetrimide Generally used as a cream for topical use. Also used for : Prevent infection in – cuts Smaller wounds Wound cleansing Nappy rash Seborrhoeic dermatitis Minor burns Insect’s bites Sterilizing surgical instruments etc.

9. Side effects Erythematous rash, redness Itching, skin irritation Paresthesia Death of body tissue Hypersensitivity reaction.

10. Cetosteryl Alcohol A mixture of fatty alcohols, consisting predominantly of cetyl and alcohol. Formula: CH3(CH2) nOH Melting point: 50°c .

11. Cetosteryl alcohol (Picture for reference only)

12. Functions Emulsion stabilizer Opacifying agent Surfactant-foam booster Viscosity increasing agent Emollient Widely used in creams and lotions.

13. Liquid paraffin Also known as paraffinium liquidum , is a very highly refined mineral oil used for medicinal purposes. Function: to moisturize, soothe, improve the texture of skin.

14. At a glance.. Cetrimide Active ingredient Cetostearyl alcohol Opacifying & viscosity increasing agent; surfactant Liquid paraffin Oleaginous vehicle Distilled water Solvent

15. Apparatus Two beakers Glass rod Thermometer container

16. Procedure Step 1: measured ingredients in a top loading balance. Step 2: heated distilled water in water bath at ( 60°c - 70°c ) Step 3: took one beaker, prepared oil phase. Cetosteryl Alcohol was dissolved in liquid paraffin with the help of hot distilled water. (Picture for reference only)

17. Procedure cont’d: Step 4: took another beaker, prepared water phase. Cetrimide was dissolved in purified water in the same temperature. Then, dissolved the warm oily phase into aqueous phase. Stirred continuously until emulsion is formed & cool. (Picture for reference only)

18. Procedure cont’d: Used a glass rod to transfer the mixture to a container or tube. Finally, it was ready for labeling and packaging. Labeling: All written, printed or graphic material passing various information of the product stocked to the container of the product is known as label.

19. Precaution All the ingredients are weighed with great care. The final volume of the preparation was taken into the container with care. The container was closed tightly.

20. Composition: Each 5 gm contains 1.5 mg of cetrimide Indication: wounds, cuts, insect’s bite etc. Side effects: No severe side effects Caution: For external use only. Storage: Store in cool and dry place Batch no: 294419 DAR no: 2019-222-531 Mfg. Lic . No : 2944 Mfg. date: December 06, 2018 Exp. date: December 06, 2020 MRP: 25 tk only. SARAS Pharma Ltd. Savar , Dhaka.1342

21. Thank you..