Preparations of suppository

An introductory outline

1. PREPARATIONS OF SUPPOSITORY BY: MASH’HOOD MAHMOOD KHAN SHAHID …………….……. D14E121

2. INTRODUCTION Solid unit dosage form intended for insertion into body orifices where it melts, soften or dissolves and exerts systemic or localized effects.

3. PREPARATION Followings are the methods meant for manufacturing of suppositories; HAND ROLLING COMPRESSION MOLDING FUSION MOLDING AUTOMATIC MOLDING MECHINE

4. HAND MOLDING It is the oldest and simplest method. This method is employed for small scale production.

5. COMPRESSION MOLDING This method follows the same procedure as that of hand molding except the base containing the drug is compressed into suppositories using a hand operated machine . ADVANTAGES: It is a simple method skipping the task of hand rolling. Suppository formed is more elegant than hand molded one. It avoids the possibility of sedimentation of the insoluble solids in the suppository base. DISADVANTAGES: Entrapping of air may occur causing Weight variation Oxidation of drug or base used.

6. FUSION MOLDING This is the approach exercised on both small and large scale industry due to its efficacy. The melted mass of the base containing the drug is poured into suppository molds.

7. AUTOMATIC MOLDING MECHINE This is the modern and automated method for formulation of suppositories. The molding function is completely done by machine. Typical rotary machine turn out 3500-6000 suppositories per hour.

8. MOLD Omitting hand molding, rest of the methods engage a die for imparting specific shape to the mold. These could of different shapes.

9. KHSN’S PRODUCTION