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1. HITEKSHA BHALARA
Pancreatic Cancer

2. EPIDEMIOLOGY

5. Risk Factors
•Smoking, Obesity, and Chronic pancreatitis
•DMII, High intake of Fat and/or Meat (particularly smoked or processed
meats), physical inactivity
•Genetic susceptibility may play a role in 5-10% of cases
•Familial history of pancreatic cancer, hereditary cancer syndromes, Peutz-
Jeghers Syndromes,BRCA-2 mutations all associated with increased risk of
pancreatic cancer

6. Types of pancreatic tumors

7. Diagnosis
•Proper history
•Physical examination: lymph node enlargement, jaundice,
hepatosplenomegaly, ascitis etc.
•Lab tests: CBC, liver function tests
•CA19-9 test (most useful tumor marker) - elevated in 70%-90%
•Instrumental tests: CT scan most commonly used
•X-ray: for pulmonary metastasis
•Pathology: ultimately required - biopsy by endoscopic ultrasound

8. Staging

9. Treatment
•Surgical treatment: 1. Resectable PDAC (if tumor is localised)
• 2. Whipple procedure (if tumor is in head of pancreas)
• 3. Distal pancreatectomy (if tumor in the body of pancreas)
• 4. Total pancreactectomy
•Adjuvant therapy: Chemotherapy- Folfirinox, Gemcitabine with nab-paclitaxel
• Radiation therapy with combination of chemotherapy for
advanced stage cancer

10. THANK YOU