Presentation about chronic Pancreatitis

Presentation of chronic pancreatitis

1. Chronic Pancreatitis Your Name Date Institution

2. Definition Chronic pancreatitis is a progressive, irreversible inflammatory disease Characterized by permanent structural damage Leads to exocrine and endocrine dysfunction

3. Etiology Alcohol abuse (most common) Idiopathic Genetic (e.g., PRSS1, SPINK1 mutations) Autoimmune Obstructive (e.g., tumors, strictures) Tropical pancreatitis

4. Pathogenesis Repeated inflammation leads to: - Fibrosis - Loss of acinar cells (↓ exocrine function) - Islet cell destruction (↓ insulin = diabetes) - Ductal obstruction and calcification

5. Clinical Features Abdominal pain (epigastric, radiates to back) Malabsorption (steatorrhea, weight loss) Diabetes mellitus Jaundice (if bile duct is compressed) Pancreatic calcifications

6. Diagnosis History + clinical symptoms Imaging: - Abdominal CT: calcifications, ductal dilatation - MRCP/ERCP Functional tests: - Fecal elastase (↓ in exocrine insufficiency) Blood glucose: check for diabetes

7. Complications Pancreatic pseudocysts Diabetes mellitus Biliary obstruction Pancreatic cancer (↑ risk) Malnutrition

8. Treatment 1. Lifestyle: - Alcohol & smoking cessation - Low-fat diet 2. Medications: - Pancreatic enzyme supplements (e.g., Creon) - Analgesics (e.g., paracetamol, tramadol) - Insulin for diabetes - PPIs if enzymes are not working well 3. Endoscopic/Surgical: - Drainage of pseudocysts - Ductal decompression - Partial pancreatectomy in selected cases

9. Prognosis Progressive but variable Better outcomes with early lifestyle modification Monitoring for complications is essential

10. Summary Chronic pancreatitis is irreversible and leads to pain and functional loss Multifactorial etiology, alcohol being the most common Diagnosis is clinical and radiologic Management is supportive and preventive

11. References Harrison’s Principles of Internal Medicine UpToDate NICE Guidelines on Chronic Pancreatitis