presentation on pharmacology of peptic ulcer

peptic ulcer

1. RITEE COLLEGE OF PHARMACY PEPTIC ULCER Guided By: Mr Tushar Verma Associate professor RITCOP, Raipur Submitted by: Snehil Parpyani B Pharm 7 th sem Roll no: 311304119054

2. Index Introduction Physiology of gastric acid secretion Drugs for peptic ulcer Adverse effects Reference

3. Introduction: Peptic ulcer occurs in that part of gastrointestinal tract which is exposed to gastric acid and pepsin. i.e. stomach and duodenum It occurs due to imbalance between: Aggressive factors Defensive factors *A cid *gastric mucus *Pepsin *bicarbonate secretions *Bile *prostaglandins * Helicobacter.pylori *nitric oxide

4. Types of peptic ulcer i n gastric ulcer : acid secretion is normal or low, it is caused due to impaired mucus and bicarbonate secretions. In duodenal ulcer: it is caused due to high acid secretion, defensive factors have no role in it. Whether production of acid is normal or low, it does contribute to ulceration as an aggressive factor.

5. SYMPTOMS Abdominal discomfort Fatigue Weight change Bloating Chest pain Burping Nausea Anorexia

6. Physiology of gastric acid secretion Gastric acid (HCL) is secreted in parietal cells in the stomach by exchange of ions in the proton pump present in it. The terminal enzyme H+K+ATPase enzyme(proton pump)which secretes H+ ions in the apical canaliculi of parietal cell can be activated by histamine, Ach, gastrin acting via their own receptor

7. Physiology of gastric acid secretion

8. Drugs For Peptic ulcer

9. Gastric acid secretion inhibitors H2 A ntihistaminics :