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1. Defecation becoming more frequent (more than 3 times for the last 24 hours, for breast-feeding children more than 5-7 times) or/and dilution of feces Diarrhea is an increase in the frequency of bowel movements or a decrease in the form of stool (greater looseness of stool). Although changes in frequency of bowel movements and looseness of stools can vary independently of each other, changes often occur in both. DIARRHEA

2. In patients with diseases of the gastrointestinal tract:- Ulcerative colitis As part of irritable bowel syndrome or other chronic diseases of the large intestine Crohn's disease (ileitis terminal ) Intestinal infections Shortened guts syndrome Endocrine dyskinesia Chronic gastritis with decreased secretion POSSIBLE CAUSES OF DIARRHEA

3. In healthy individuals Drinking milk in patients with lactase deficiency Violation of the diet (an abrupt change of diet, water composition, the use of unripe fruit, overeating ) Scare ("bear's disease ") The use of drugs ( antibiotics , antacids containing magnesium salts, potassium preparations, sulphonamides , anticoagulants, digitalis, cholestyramine, sorbitol, mannitol ) POSSIBLE CAUSES OF DIARRHEA

4. The management of diarrhea consists of the replacement of lost fluid with oral rehydration solution (ORS). But , this solution does not reduce the severity and the duration of diarrhea. Therefore , probiotics are used with ORS to reduce the severity and duration of diarrhea in infants and children. MANAGEMENT OF DIARRHEA

5. Lactobacillus Probiotics are identified at three levels - Rhamnosus GG WHAT IS THE MOST IMPORTANT CRITERIA FOR PROBIOTIC SELECTION ? Selecting the specific strain is the most important criteria in probiotic selection because studies have proven that effectiveness of probiotic is strain specific.

6. WHAT IS THE MOST IMPORTANT CRITERIA FOR PROBIOTIC SELECTION ? A probiotic strain that works in one condition will not necessarily be effective for other conditions. For example, Lactobacillus Rhamnosus GG effectively prevents antibiotic-associated diarrhea, but not urogenital infections. Whereas, Lactobacillus Rhamnosus GR-1 effectively treats urogenital infections, but not antibiotic-associated diarrhea.

7. STATEMENT BY MAJOR MEDICAL BODIES “Not all commercially available probiotic preparations are effective in children. Therefore, probiotics should be selected based on effectiveness data.” Several bacteria are effective in reducing the severity and duration of diarrhea in children. But, among them Lactobacillus Rhamnosus GG has been found most effective.

8. Lactobacillus Rhamnosus GG The Pediatric Probiotic

9. Prolaxan is a strain specific probiotic specially designed to treat pediatric diarrhea. Prolaxan ( Lactobacillus Rhamnosus GG) Probiotic Name Genus Species Strain Lactobacillus Rhamnosus GG Lactobacillus Rhamnosus GG WHY PROLAXAN IS UNIQUE ?

10. OUR PRODUCT QUALITY AND FEATURES

11. Price: 40 tk /cap (800 tk./box)

12. OTHER PROBIOTICS OF INCEPTA PHARMA

13. OTHER PROBIOTICS OF INCEPTA PHARMA

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