Proteomics-An introduction to basic concepts 1

Proteomics is the large-scale study of proteins, including their structure, function, interactions, modifications, and expression levels within a biological system (e.g., cells, tissues, or biofluids). It provides insights into how proteins regulate biological processes, disease mechanisms, and potential biomarkers.

Proteomics can be applied in Biomarker Discovery – Identifying disease-specific proteins (e.g., tuberculous meningitis biomarkers).
💊 Drug Development – Understanding protein-drug interactions.
🧬 Personalized Medicine – Tailoring treatments based on protein profiles.
🦠 Infectious Diseases – Investigating host-pathogen interactions.

1. Proteomics Introduction and basic concepts

2. What is proteomics? Proteomics is the large-scale study of proteins , including their structure, function, interactions, modifications, and expression levels within a biological system (e.g., cells, tissues, or biofluids). It provides insights into how proteins regulate biological processes, disease mechanisms, and potential biomarkers .

3. Branches of proteomics Structural Proteomics – Determines the 3D structure of proteins and protein complexes. Expression Proteomics – Compares protein expression between different conditions (e.g., healthy vs. diseased states). Functional Proteomics – Investigates protein interactions, post-translational modifications (PTMs), and signaling pathways. Clinical Proteomics – Identifies biomarkers for disease diagnosis, prognosis, and therapy (e.g., in tuberculosis, cancer, and neurodegenerative diseases).