"NF-kB " Pathway: Nuclear Factor Kappa Beta

A cell signaling pathway.

1. "NF-kB " Pathway
Nuclear Factor Kappa Beta
Presented by-
MD. IDRISH RAJA KHAN
AAH-01/15
COLLEGE OF FISHERIES, CAU, Tripura

2. Contents…..
1.What is NF-Kb ?
2.Structure of NF-Kb
3.NF-Kb signaling pathway
# Classical / Canonical pathway
# Alternative / Non-canonical pathway
4. Biological Implications

3. What is NF-kB ?
The transcription factor NF-κB was
discovered in 1986 by David Baltimore.
NF-kB (nuclear factor kappa-light chain
enhancer of activated B cells) is a protein
complex that control transcription of DNA.
Considered as a prototypical
proinflammatory signaling pathway.

4. Structure of NF-kB
It composed of five related transcription
factors- p50, p52, Rel A, Rel B, c-Rel.
These transcription factors are related
through an “N-terminal DNA-binding
domain”, which bind to a verity target DNA
sequence called B sites to modulate gene
function.

5. NF-kB protein
C-terminal
domain
N-terminal
domain

6. The NF-κB signaling pathways
1. Classical / Canonical pathway
1.Binding of ligand to cell surface
adaptors.
2.Recruit the IKK complex.
3. Active NF-κB transcription factor
subunits to translocate to the
nucleus.
4. Induce target gene for
expression.

7. 2. Alternative / Non-canonical pathway
1.Binding of ligand to cell surface
adaptors.
2. Activation of NIK
3. Phosphorylates and activates
an IKK alpha complex that in
turn phosphorylates the IκB
domain
4. Active NF-κB transcription
factor subunits to translocate to
the nucleus.

8. Biological Implications :-
1.Cancers
2.Inflammation
3.Addiction
4.In immunity
5.cellular development
6.cellular survival