Ranitidine (Anti ulcer) by Gaurav Naik

RANITIDINE (Anti-Ulcer Drug)
Pharmacokinetic and Pharmacodynamic of Ranitidine

1. VIGHNAHARATA TRUST`S
SHIVAJIRAO S. JONDHLE
COLLEGE OF PHARMACY, ASANGAON
1
DRUG INFORMATION -RANITIDINE (ANTI-ULCER)
PRESENTED BY
MR. GAURAV S. NAIK
FINAL YEAR B.PHARMACY
GUIDED BY :
DR. NITIN C. MOHIRE
PROFESSOR AND PRINCIPAL

2. RANITIDINE
Molecular formula : C13H22N4O3S
IUPAC Name :N-(2-[(5-[(Dimethylamino)methyl]furan-2-yl)
methylthio]ethyl)-N'-methyl-2-nitroethene-1,1-diamine
•Ranitidine is a histamine-2 blocker.
•It reduces the amount of acid in stomach.
•It is used to treat and prevent ulcers.

3. PHARMACODYNAMICS
RANITIDINE
Completely blocks H2 receptors by Reversible binding
inhibition of Histamine binding to this receptor
Decreases cAMPformation
Reduction of Gastric acid secretion
Healing of Ulcer
MOA :-

4. ADVERSE EFFECTS :
•Various types of cancer.
•Liver disease.
•Enlarged liver.
•Reduced kidney function.
•Jaundice
•Nausea
SIDE EFFECTS :
•Headache.
•Abdominal pain.
•Agitation.
•Hair loss.

5. USES:
1.Anti-ulcers in the stomach and intestines.
2.To treat Zollinger-Ellison syndrome.
3.To treat gastro-esophageal reflux disease (GERD).

6. PHARMACOKINETICS
Absorption:
Ranitidine Tablets is 50% absorbed after oral administration.
Bioavailability is 50% (by mouth)
Distribution:
Volume of distribution is about 1.4 L/kg.
Serum protein binding averages 15%.
Metabolism:
Organ :-Liver
Metabolites :-N-oxide is the principle metabolite (<4 % of the dose)
S-oxide (1%) , Desmethylranitidine (1%)
Excretion:
Organ–Kidney (30 –70 %)
Renal clearance is about 410 mL/min

7. DOSE : 150 mg orally 2 times a day before meal
Or 300 mg orally once a day before meal.
Dosage form : Tablets (oral and effervescent)
Syrup
Injectablesolution
Brand name : Zantac tablets
Company name : GlaxoSmithKline (GSK)

8. THANK YOU!!!