Rapaport leubering cycle

Glycolysis alternate

1. RAPAPORT-LEUBERING CYCLE Supplementary pathway to Glycolysis

2. Glucose Glyceraldehyde 3-phosphate 1,3-Bisphosphoglycetate

3. 2,3-Bisphosphoglycerate 3-phosphoglycerate Pyruvate

4. This is supplementary pathway to glycolysis . These operative in the erytrocyte of man and other mammals. Rapaport leubering cycle mainly concerned with the synthesis of 2,3-bisphosphoglycerate (2,3-BPG) in RBC.

5. 1,3-Bisphosphoglycerate(1,3-BPG) produced In Glycolysis is converted to 2,3-BPG by the Enzyme 2,3-bisphosphoglycerate mutase . 2,3-BPG is hydrolysed to 3-phosphoglycerate phosphatase

6. About 15-25% of the glucose Converted to lactate in erythrocytes Goes via 2,3-BPG synthesis. Important fact