Rbc abnormality

Abnormalities in RBC Their Clinical Significance

1. RBC ABNORMALITY Ms Ankita R Bhatiya Assistant Professor Shree P.M.Patel COLLEGE OF PARAMEDICAL SCIENCE N TECHNOLOGY

2. RBC ABNORMALITY Abnormalities in RBC Their Clinical Significance : 1.Normal red blood cells a)Round cells & They have a small area of central pollar b)Only slight variation in size  

3. RBC ABNORMALITY 2. Microcytes a) Decrease in the size b)Associated with iron deficiency

4. RBC ABNORMALITY 3) Macrocytes a) Increase in the size b) Associated with Megaloblastic anaemia

5. RBC ABNORMALITY 4. Hypochromia a) Red cells with a large area of central pallor part b) Iron deficiency

6. RBC ABNORMALITY 5 . Spherocytes ( Hyperchromia ): a) Cells are not biconcave b) No central area of pallor part c ) Smaller surface area for the cell size. d) Inherited disorder or in autoimmune haemolytic anaemia

7. RBC ABNORMALITY 6. Target Cells a) These cells have a centrally stained area b) Thalassaemia , iron deficiency

8. RBC ABNORMALITY 7. Stomatocytes : These cells show an oval or rectangular area of central pallor

9. RBC ABNORMALITY 8. Anisocytosis a) A variation in the site of the red blood cells is observed b) Blood disorder

10. RBC ABNORMALITY 9. Poikilocytosis a) A variation in the shape of red blood cell is observed b) Blood disorder

11. RBC ABNORMALITY 10. Sickle cells a) Red cells in the shape of a sickle or crescent b) They come to a point at one end

12. RBC ABNORMALITY 11. Ovalocytes : Oval shaped red cells

13. RBC ABNORMALITY 12. Elliptocytes : More oval than Ovalocytes (Cigar shaped)

14. RBC ABNORMALITY 13. Acanthocytes a ) Red cells with sharp, irregular, thorn like projections on the outer edge b) Associated with abnormal phospholipids metabolism

15. RBC ABNORMALITY 14. Burr cells a) Red blood cells with pointed projections on their outer edge b) Occur as an artefact or uraemia & some other conditions

16. RBC ABNORMALITY 15. Basophilic stippling a) Presence of fine or coarse purple staining granules in the red cells b) Thalassaemia , lead poisoning, infections & blood disorder

17. RBC ABNORMALITY 16. Siderocytes ( pappenheimer bodies) a) Purple coloured granules of iron in led cell b) Haemolytic anaemia after Splenectomy

18. RBC ABNORMALITY 17.Howell-Jolly body Round purple staining nuclear fragments in the red blood cell h) Seen in Post- splenectomy patients & also appear in haemolytic & megaloblastic anaemia

19. RBC ABNORMALITY 18. Cabot ring a) Purple staining, thread like filaments in the shape of a ring in red cell b) Haemolytic & megaloblastic anaemia

20. RBC ABNORMALITY 19. Schistocytes a) Red blood cell fragments b) Intravascular haemolysis & disseminated intravascular coagulation

21. RBC ABNORMALITY 20. Crescent bodies Ruptured red cells in the shape of a quarter moon

22. RBC ABNORMALITY 21. Creneted cells a) Red cells having irregular outer edges. b) This is often due to faulty drying of blood smears

23. RBC ABNORMALITY 22. Heinz bodies It is found in patients with glucose-6-phosphate deficiency and the patient is prone to drug induced anaemia or chemical poisoning