RBC - Anemia.pptx RBC, Anemia, Hemolysis - Extravascular hemolysis , Intravascular hemolysis in detail.

RBC, Hemolytic Anemia

1. Anemia Anemia is a reduction in the total circulating red blood cells (RBC) mass below normal limits, due to reduced oxygen carrying capacity and tissue hypoxia. It is diagnosed based on decrease in RBC count, Hct, Hb concentration in the blood. Hb <13.5g/dl in males Hb <12.5g/dl in females

2. Hemolysis : premature RBC destruction. Extravascular hemolysis Intravascular hemolysis -Major mechanism -Macrophage mediated -Spleen,liver,bone marrow -Minor mechanism -In blood vessels -trauma,injury,infection Rbc phagocytosis → Heme + Globin Iron stores Bilirubin Unconjugated bilirubin Albumin Conjugated bilirubin (liver) Rbc lysis → Haptoglobin + free Hb in plasma in plasma Cleared via kidney -Anemia -Jaundice -Hyperbilirubinemia -Splenomegaly -Hepatomegaly -Anemia -Jaundice (mild) -Hemoglobinemia -Hemoglobinuria -Hemosiderinuria - ↓ Haptoglobin