Receptor Classification and Structure.pptx

Receptor Classification and Structure , GPCR , Enzyme linked receptor

1. PRESENTED BY : NIBE CHETAN DATTATRAY F.Y.M PHARM ( DEPT OF PHARMACOLOGY ) GUIDED BY : DR. S.B.DIGHE HEAD OF DEPARTMENT PHARMACOLOGY Receptor Family And Molecular Structure:

2. Introduction Receptors are proteins that interact with specific ligands to initiate biological responses. They are essential in cell signaling and play a crucial role in physiological and pathological processes specialized

3. Classification of Receptors 1. Ligand-Gated Ion Channels 2. G-Protein Coupled Receptors (GPCRs) 3. Tyrosine Kinase Receptors 4. Nuclear Receptors

4. Ligand-Gated Ion Channels / Ionotropic Receptor Definition: Ligand-gated ion channels are ionotropic receptors that open in response to ligand binding, allowing ion flow across the membrane. Examples: - Nicotinic acetylcholine receptor - GABA-A receptor Molecular Structure: - Multi-subunit protein complexes forming a pore for ions.

5. G-Protein Coupled Receptors (GPCRs) Definition: GPCRs are transmembrane receptors that activate intracellular signaling pathways via G-proteins upon ligand binding. Examples: - Beta-adrenergic receptor - Rhodopsin Molecular Structure: - Composed of seven transmembrane alpha-helices connected by loops.

6. Tyrosine Kinase Receptors / Cytokinse Receptor Definition: Receptors with intrinsic enzymatic activity that phosphorylate tyrosine residues on target proteins upon activation. Examples: - Epidermal growth factor receptor (EGFR) - Insulin receptor Molecular Structure: - Extracellular ligand-binding domain - Single transmembrane domain - Intracellular kinase domain.

7. Nuclear Receptors / Steroid Hormone Definition: Intracellular receptors that bind to ligands like hormones and directly interact with DNA to regulate gene expression. Examples: - Estrogen receptor - Glucocorticoid receptor Molecular Structure: - Ligand-binding domain - DNA-binding domain - Activation domain.

8. Conclusion Receptors are vital for cellular communication and signal transduction. Understanding their classification and structure provides insights into their functions and potential as drug targets.