Reductive biosynthesis

slides on reductive biosynthesis

1. Reductive Biosynthesis It is defined as; Anabolic pathway that require hydride ion to reduce carbon atom in metabolic intermediates. It is synthesis of large molecules from smaller ones that are used in formation of cellular components. E.g. Proteins from amino acids DNA from nucleic acid Lipids ,vitamins, glycogen etc.

2. Reducing agents Hydride ion is given by reducing agents that are different from laboratories ones. They are NADH,FADH2,FMNH2,NADPH. They are found in redox pair ant get deoxidized in other reactions. In reductive biosynthesis, only NADPH is discussed because other ones are used in catabolic processes.

3. NADPH Used in HMP,PPP. Fatty acid synthesis. Gluconeogenesis. Protein synthesis.

4. Fats synthesis Cholesterol is taken by diet and produced in liver's cytosol, 800 mg per day. Palmitic acid is primary one. At each step elongation of 2 carbon atom is done.

5. Pathway integration Other pathways are integrated which are Protein degradation Carbohydrate metabolism

6. Synthesis Acetyl CoA and CO2 reacts to form malonylCoA i.e. Intermediate.