CONTENTS INTRODUCTION DEFINITIONS HISTORY CONCEPTS OF REGENERATIVE ENDODONTICS CHALLENGES AND FAILURES FUTURE DEVELOPMENT IN REGENERATIVE ENDODONTICS CONCLUSION REFERENCES
INTRODUCTION Tooth development is a complex and long process of postnatal organogenesis . A tooth may take an additional 3 years after eruption to complete its root maturation. Endodontic treatment of necrotic immature human permanent teeth has always been challenging Traditionally these teeth were managed by apexification: calcium hydroxide or mta resolve the signs and symptoms with little or No continuous root development The frequency of cervical root fractures was markedly higher in endodontically treated immature teeth - ranged in incidence from 28%–77% Regenerative Endodontic Procedures: Clinical Outcomes , Anibal Diogenes
Regenerative endodontic procedures can be defined as biologically based procedures “designed to replace damaged structures”, including dentin and root structures, as well as cells of the pulp-dentin complex. REGENERATIVE ENDODONTICS TISSUE ENGINEERING An interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain or improve tissue function Regenerative endodontics : A review of Current status and a call for Action – Murray, Garcia Godoy and Hargreives - 2007