Substances Effect on Pregnancy Alcohol Spontaneous abortion, LBW, IUGR, FAS, ARBD, MR Caffeine Vasoconstriction & mild diuresis in mother, fetal stimulation Nicotine Vasoconstriction, ↓ utero -placental flow, LBW, Abortion Cocaine Vasoconstriction, GHTN, Abruptio Placentae, snow baby syndrome, CNS Defects, IUGR Marijuana Anemia, ↓ weight gain, Amotivational syndrome, newborn tremors, prematurity & IUGR. 6. Narcotics Maternal & Fetal withdrawal, Abruptio placentae, preterm labor, PROM, asphyxia, newborn sepsis, intellectual impairement , malnutrition Sedatives CNS Depression, newborn withdrawal , maternal seizures in labor, newborn abstinence syndrome, delayed lung maturity