RODENT ULCER.pptx

Rodents ulcel general pathology

1. P R E S E NTED B Y : J O H N R . S U N G O H R O L L N O . 1 1 4 B D S 2 n d YEAR

2. B A S A L C E L L CARCINOMA ( R O D E N TS U L C E R ) DEF I NITION It's a s low g r o w ing . locally invasive . M a l i g n ant t u m o r o f e p i t h e l ial c e l l s . A r i s e from basal e p i d e r m is a n d h a i r follicles C o m m o n e s t m a l i g n ant s k i n t u m o r A l s o c a l l ed " Rodent " O r " T e a r " C a n c e r O r B a s a l C e l l E p i t h e l i o m a

3. It was called a rodent ulcer because this kind of cancer sometimes looks like a tiny rodent bite on the skin.

4. EPIDEMIOLOGY A g e : 4 - 8 Y e a r s ( 9 5 % ) . S e x : M a l e : F e m a l e ( 3 : 1 ) . 8 % a r i s e i n h e a d a n d n e c k . 9 % i n f a c e . F a i r s k i n n e d > d a r k s k i n n ed p e o ple .

5. E T I O L O GY H i g h R i s k F a c t o r s O n e x p o s ure t o : * U . V light A r s e n i c C o a l t a r X - r a y s I n f r a r e d r a y s A l s o genetic s k i n c a n c e r s y n drome s

6. C L I N I C A L F E A T U R E S S t a r t a s a s m a l l nodule . U l c e r f o r m a t ion w i t h r a i s e d a n d r o l l e d edge . C e n t r al p a r t i s c o v e r ed w i t h s c a b . G r o s w s v e r y s l o w l y . N o l y m p h n o d e L o c a l d e s t r u c tion b y i n f i l t r a t i o n .

7. E N L A R GE V I E W : N o d u l e , I r r e g ular i n shap e , w i t h r a i s e a n d r o l l e d e d g e .

8. S I T E F O R B A S A L C E L L C A RCINOMA I n the m i d d le 1 / 3 o f f a c e ( 9 % ) M e d i a l c a n t h u s o f t h e e y e L a t e r a l c a n t h u s o f t h e e y e . N o s e E y e l i d C h e e k , E a r S c a l p N e c k H a n d e t c .

9. M O R P H O L O G I C F E A T U R E S I t 's i s : A s l o w g r o w i ng t u m o r . With r a r e m e t a s ta sis . L o c a l i n v a sion . D i s f i g u r e m e n t . N o t s p r e ad t o o t h e r o r g a n

10. P A T H O G E N E SIS N o a p p a r e nt p r e c u rsor l e s i o n H a r d t o c u l ture R e s i s t transplantation R a r e m e t a s t asis ( 1 7 % ) B u t r e c u r r e nt k n o w n a f t er i n a d e q uate t r e a t m ent . mutation i n T P 5 3 g e n e .

11. H I S T O P A T H O L O G Y I r r e g u lar m a s s e s o f b a s a l o i d c e l l s . A r r a n g e i n n e s t s . S h r i n k a ge a r t i f a c t C l e f t b / w B . C C n e s t and s t r o m a C l e f t p r e s e n t d u e t o s h r i n k a ge o f m u c i n i n t h e s t r o m a .

12. S U B T Y P ES O F B . C C * ( 2 6 varieties o f B . C C ) 6 s u b t y pes a r e : N O D U L A R B . C C P I G M E N T E D B . C C C Y S T IC B . C C S U P E R F ICIAL B . C C ( A r s e n i c ) M I C R O N U D U L A R B . C C M O R P H O E I C B . C C

13. INVESTIGATION S S K I N B I O P S Y X-ray O F T H E P A R T C T - S C A N

14. T R E A TMENT : S U R G I C AL E x c i s i on M O H S M I C R O G R A P H Y S U R G ERY 2 . R A D I O T H E R A P Y 3 . N O N - S U R G I C A L E l e c t r o Dissication L a s e r v a p o r i z a t i o n ( i n m u l t i ple t u m o r s )

15. THANK YOU