Rotary Evaporator. Modern techniques of Evaporation.

It consists of introduction to rotary evaporator it's principal, parts, working, procedure and application.

1. B. Pharm Sem-VII Presentations
Rotatory Vacuum Evaporator
IN THE SUBJECT
Pharmaceutical Chemistry
Bhujbal Knowledge City,
MET’s Institute of Pharmacy,
Adgaon, Nashik, 422003.
Maharashtra, India
Academic Year2022 -23
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Presented By-
Yogita Ahire
B. pharm Final Year
Roll No. 06
Guided By :
Mr. Shantanu ghodake
Ms. Poonam Wajepye
Pharmaceutical
Chemistry
Principal:
Dr. S. J. Kshirsagar

2. CONTENTS
•Introduction
•Principle
•Schematic Presentation
•Parts Of Rotatory Vacuum Evaporator
•Working
•Procedure
•Industrial Application
•Reference
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3. INTRODUCTION
•Rotatory evaporator are the device used to remove volatile solvent
from non volatile solute
•It is use to remove solvent from the solute to collect product
•Rotatory evaporator is also known as ‘ROTAVAP’
•This is help to encourage rapid elimination of excess solvent from
less volatile solvent sample
•Rotatory evaporator is used to perform EVAPORATION UNDER
LOW PRESURE.
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4. PRINCIPLE
•The rotatory vacuum evaporator consist of heating bath with rotating flask,
in which liquid to be evaporated is placed.
•Under vacuum the liquid is evaporated in the flask.
•A rotatory evaporator is fast and effective technique to separate solvent
from solute. It may liquid-liquid evaporation ither liquid solid evaporation.
•The rotatory flask is continuously rotating and centrifugation force is
formed, so as to increase evaporation surface area per unit time. And liquid
is evenly distributed to the wall of flask with the constant heating to the
solvent and liquid is get evaporated more evenly.
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5. •Solvent with low boiling point can be evaporated in to the rotavapwithout
overheating and are get separated under constant pressure.
•The evaporated liquid is cooled by condenser and collected in to another
flask.
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6. Schematic Presentation Of Rotatory
Evaporator
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7. Parts of Rotatory Vacuum Evaporator
•Rotatory motor: Rotate evaporating flask, increase the surface area
of solvent
•Vacuum gauge: Responsible for creating vacuum, thereby reducing the
pressure within the system
•Heating bath: used to heat solution of the evaporating flask which increase
evaporating rate.
•Condenser: the condenser evaporate sample as well as enhance converse
sample selection
•Receiving flask: to receive distillated sample
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8. WORKING
•A rotatory vacuum evaporator is a device used to remove solvent from the
sample by the evaporation. It is obtained used to concentrate sample before
analysis. The device connected to rotatory flask that is connected to the
vacuum pump. The vacuum pull the air out of the flask and create a
vacuum. This vacuum allow the solvent to evaporate quickly. The sample is
placed in to flask and vacuum is turned on, the flask is then rotate and
allow the sample to evenly evaporated
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9. PROCEDURE
All the equipment and glasswaresare neatly cleaned and dry
Assemble the rotatory vacuum evaporator
Fill the round bottom flask no greater than half-full
Connect to the bump trap with plastic clip
Lower the flask in to water bath to submerge the liquid
( don’t submerge to the plastic clip)
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10. Connect the vacuum line in to the rotating vacuum evaporator and turn on
vacuum meter
Rotate the flask at moderate speed and slowly increase the temperature of the
water bath and allow to evaporate until the desired volume is recived
Disconnect the vacuum lid and turn of the vacuum pump
Remove the flask from rotatory vacuum evaporator and allow to cool it and
once the sample is cooled it can transfer to the suitable container.
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11. Industrial application
1.Cleaning of organic solvent: chloroform, benzene, etc.
2.Extraction of natural products: plant extract, animal extract.
3.Concentration of microbiological products: bacteria, protein, enzyme.
4.Concentration of inorganic solvent , organic salts.
5.Removal of solvent, drying of solvent such as alcohol, ether, etc.
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12. REFERENCE
•Roopkhar, S. P. Vyas, Farhan J. Ahmad, Gaurav Jain, Lachman/ Libermans
the theory and practice of industrial pharmacy, CBC Publication, 4
th
publication, pg. no. 74-75.
•Miller, K. A. Liu, D. Braun, P. V. Rotatory EVAPORATOR Standard
Operating Procedure. Lab 3724 and 3710 Beckman Institute, Material
science and engineering.
•rotatory vaccumeevaporator diagram -Bing images
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13. Thank you….
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