Síntese Orgânica - Introdução

3. à quando ingd
a dos produtos ind
Fe outros comtipostos aid
os os anos@Mmnilhares de novos

da Oni processo de obtençäo de co:
AN La Wapples transformagáo química e1
& acdes químicas em sequéncia.

a Criaçäo de um campo de gy

Und projeto de síntes

imento$ a respeito de métodos sintéticos,

ge análise (IV, RMN, eic.), entre outr

a foi introduzido por E. J. Col
nsével, hoje, para qualqug

4. NH,*NCO>

nto da Quimica ad

5. ativaffrustrada de preparacáo da quiking

aminho para o o y

6. Penicilina
intese da Reserpina
Sintese do Dodecaedrano

R. Willstate (1915)
R. Robinson (1917)
R.B. Woodward (1945)

J.C. Sheehan (19
R.B. Woodw
L. Paquete (19

7. +
Me OH Me ”

Palitoxina

8. 2 mv
, partir de mater
i comercialmg

9. 3) A de-¿málogó We
com atividad e biológ icf

+

11. D cogcentna .
uire Uma carga parcial

negativo adquire carga

H,C—CH,

ethane

nonpolar

12. rai os eléfrons do hidrogé

SS

E 0 produto das magnitudes, ee
eletrostáticas: esu) e a dist:
A unidade de medi
1x108 esu cm
Dipole moment

13. Formula

He
eb
HF
HCl
HBr
HI
Bl

and negative

sd Sy)

Formula

14. H=19D | u=39D

chloromethane hlor acetonitrile

15. es, are characterized
eldurrangement of ato
TROWSIO

Carbon-Carbon
bonds are gen

xy)

16. orogen from an 4

ALKYL GROUP.
CHy—
Methyl group
CH,CH, CH,CH,— or C3H;—
Ethane Ethyl group
>H,CH,CH

Propane

“HCH, CH SHES or CH¿CH

Propane Isopropyl group

Methyl
Ethyl others

CH,CH,CH, Propyl an be
CH,CHCH esignated by R.

17. or CcHs— or Ph— or d— or Ar—(if ring substituents are present)

Ways of represent enyl group

methyl hydrogg
inzyl p

—CH5— or (E )}-CH— or CC, — or Bn—

Ways of representing a henzyl grou
N

18. HS

|

HH
A L alkyl
chloride

19. CH,CH 1

+ Ethane Ethyl

20. = This is a differgÚ y
alcohols

22. General formu

23. cue

Acetamide

24. Functional
Ñ bond

These names are

Alkene Alkyne | Aromatic

Ethy

Haloalkane

Alcohol

H,OH

Dimethyl eth

25. Aldehyde

RNH,
R,NH
RN

ethylamine

Methyl acetate

Nitrite

nenitrile

Acetonitrile

26. these are nucleophiles because they
have a pair of electrons to share

27. Ht CH,CH) BH;

‘Br° RO:

AA

these are electrophiles because they
can accept a pair of electrons

these are electrophiles because
they are seeking an electron

www.qmelink.com

28. Introduçäo à Sintese Organica 20/08/2010

Electrophilic Addition of HBr to Alkene

# $

CH¿CH=CHCH;z + H—Br CH¿CH cu + Br — CH,;CH—CHCH;
H Br H

a carbocation 2-bromobutane

an alkyl halide

www.qmelink.com

29. um par de elétrons

>.

to de um elétron

EN

30. Utilizaçäo dé Sétas curvas

CH,;CH=CHCH, + H—Br —> CH;CH A + ¿Br
H

ae + Bn —> CHsCH—CHCHs
H Br H

www.qmelink.com

31. correct

CH; 0H — CH;

HA
[correct

[incorrect]
5)

|

CH;
CHAS H — CH,—Ö—-H + H

|
H

\
[incorea]

ww.gmelink.com

32. Introduçäo à Sintese Orgánica

CH;CH=CHCH; + H~Br: — CHHÈH—CHCH, +

correct

CH¿CH=CHCH, + H—Br — CH,;CH—CHCH; +
|
H

H

incorrect

= Mata]

yo
¡OH

ll I
+ CH;CCH; — CH;CCH; + H™

www.qmelink.com

33. the highest
energy state
free energy on the reaction
of the pathway
reactants
free energy
of the
products

>
oO
=
©
£
©
y
o
te
ira

34. im. Nova@2002; Vol. 25,