Schmidt Rearrangement.pptx

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1. Schmidt Rearrangement The Schmidt reaction is the reaction of hydrazoic acid or an alkyl azide with a carbonyl compound, alkene, or alcohol, often in the presence of a Brønsted or Lewis acid . The product is an amine, imine, or amide, with the expulsion of nitrogen  Applications of Schmidt Reaction The Schmidt reaction can be applied to prepare amino acids, diamines , cyclic amides, lactams, and tetrazole . Each one of these compounds has a unique application. For example, amino acids are used by the industry in the synthesis of drugs and cosmetics

2. The acid- catalysed reaction of hydrogen azide with electrophiles, such as carbonyl compounds, tertiary alcohols or alkenes. After a rearrangement and extrusion of N 2 , amines, nitriles, amides or imines are produced.