Sclerosing agents

Mumbai University FY B Pharm Sem I

1. SCLEROSING AGENTS SCLEROSING AGENTS
Dr Taj Khan
Dept. of Pharmaceutical Chemistry, Oriental College of Pharmacy,
Sanpada, New Mumbai.

2. IntroductionIntroduction
SCLEROSING AGENTSSCLEROSING AGENTS
sodium morrhuatesodium morrhuate
Sodium tetradecyl sulfate (STS)Sodium tetradecyl sulfate (STS)

3. Sclerosis:Sclerosis:
- Abnormal hardening of body tissue.- Abnormal hardening of body tissue.
-In medicine, -In medicine, sclerosissclerosis (also spelled (also spelled
sclerosussclerosus ( (GreekGreek "hard") is the stiffening "hard") is the stiffening
of a structure, usually caused by a of a structure, usually caused by a
replacement of the normal organ-specific replacement of the normal organ-specific
tissue with tissue with connective tissueconnective tissue..

4. Introduction Introduction
SCLEROSING AGENTS:SCLEROSING AGENTS:
Definition:Definition:
are substances that cause a marked are substances that cause a marked
tissue irritation or thrombosis with tissue irritation or thrombosis with
subsequent local inflammation and tissue subsequent local inflammation and tissue
necrosis resulting in fibrosis and tissue necrosis resulting in fibrosis and tissue
contraction. e.g. contraction. e.g.
sodium morrhuate,sodium morrhuate,
Sodiumtetradecylsulfate(STS).Sodiumtetradecylsulfate(STS).

5. Sclerosing agents:Sclerosing agents:
are some injections which are given to are some injections which are given to
irritate and damage the wall of a vein irritate and damage the wall of a vein
resulting in its occlusion eg. Closing. This resulting in its occlusion eg. Closing. This
is done in the case of varicose veins, is done in the case of varicose veins,
haemorrhoids. haemorrhoids.
Varicose veinsVaricose veins : veins that have become : veins that have become
enlarged and twisted. The term commonly enlarged and twisted. The term commonly
refers to the veins on the leg, although refers to the veins on the leg, although
varicose veins can occur elsewhere.varicose veins can occur elsewhere.

6. varicose veinsvaricose veins

7. varicose veinsvaricose veins

9. SCLEROSING AGENTSSCLEROSING AGENTS
sodium morrhuate Injection:sodium morrhuate Injection:
-It is a sterile solution of the sodium salts of -It is a sterile solution of the sodium salts of
the fatty acids of Cod Liver Oil having the fatty acids of Cod Liver Oil having
50mg of sodium morhuate per ml. 50mg of sodium morhuate per ml.
An antimicrobial agent (NMT 0.5%) and An antimicrobial agent (NMT 0.5%) and
ethyl/ benzyl alcohol (NMT 3%) is usually ethyl/ benzyl alcohol (NMT 3%) is usually
added. added.

10. is prepared by the saponification of is prepared by the saponification of
selected Cod Liver Oils.selected Cod Liver Oils.
Morrhuate Sodium occurs as a pale-Morrhuate Sodium occurs as a pale-
yellowish, granular powder with a slight yellowish, granular powder with a slight
fishy odour and is soluble in water and in fishy odour and is soluble in water and in
alcohol.alcohol.
Use: As sclerosing agent, for varicose Use: As sclerosing agent, for varicose
veins.veins.

11. Sodium tetradecylsulfateSodium tetradecylsulfate(STS)(STS)
It is It is 7-ethyl-2-methyl-4-undecanyl sulfate 7-ethyl-2-methyl-4-undecanyl sulfate
sodium salt. Sotradecolsodium salt. Sotradecol
-is a sclerosant drug, used in the treatment is a sclerosant drug, used in the treatment
of varicose and spider veins of the leg, of varicose and spider veins of the leg,
during the procedure of sclerotherapy.during the procedure of sclerotherapy.

12. Being a detergentbased chemical, its
‐
Being a detergentbased chemical, its
‐
action is on the lipid molecules in the cells action is on the lipid molecules in the cells
of the vein wall, causing destruction of the of the vein wall, causing destruction of the
internal lining of the vein and eventual internal lining of the vein and eventual
sclerosis of the vein.sclerosis of the vein.
It is used in concentrations ranging from It is used in concentrations ranging from
0.1%to3% for this purpose.0.1%to3% for this purpose.