Splenomegaly is defined by increased splenic
dimensions and volume.
Spleen diameters averaged over 13 cm and an area
above 45 cm
2 or weight above 400 g are considered
splenomegaly.
Normal Spleen Splenomegaly
Splenomegaly can be classify as;
Mild
Moderate
Massive
Mild Splenomegaly
Just palpable
(1-3) cm more than normal
spleen ≈ 14cm - 16
cm
Spleen > 400 g < 1000 g
Mild Splenomegaly with Cirrhosis
Moderate
SplenomegalyBetween costal margin & umbilicus
(4-8) cm more than normal spleen ≈ 17 cm – 21 cm
Spleen > 400 g <1000 g
Splenic Area 45 cm
2 -65 cm
2
Massive Splenomegaly
Beyond umblicus, crosses mid lineinto
pelvis
Spleen > 8cm than normal
Spleen > 1000g
Splenic area > 65 cm
2
Splenomegaly (Splenic Length) Age Group
>6.0 cm 3 months
>6.5 cm 6 months
>7.0 cm 12 months
>8.0 cm 2 years
>9.0 cm 4 years
>9.5 cm 6 years
>10.0 cm 8 years
>11.0 cm 10 years
>11.5 cm 12 years
>12.0 cm 15 years
Splenomegaly due to exaggerated forms of normal splenic function;
-
infections or inflammatory processes results from an increase in the defense activities of the
organ
-
Removal of abnormal blood cells from the circulation is the usual source of hyperplastic
splenomegaly.
- Cirrhosis with portal hypertension, splenic vein occlusion or congestive heart failure (CHF)
causes congestive splenomegaly
-
Infiltrative splenomegaly is the result of swelling of macrophages with indigestible materials.
Cysts,
Hemangiomas,
Other malformations.
Several diseases can lead to splenomegaly;
malaria, anemias etc.
Associated symptoms or signs are typically related to the underlying
disorder.
Fever
Left Upper Quadrant pain (splenic infarct) (localize area of dead cell)
Fullness and early satiety
Feeling of heaviness in LUQ
Jaundice
Most practical and cost effective
method
Perform a complete blood count (CBC) with differential, platelet
count, and peripheral blood smear
Computed Tomography
Magnetic Resonance Imaging,
Ultrasonography (High sensitivity & specificity, safe, noninvasive, quick, mobile,
and less costly)
Splenic Dimensions
Splenic Contour (Rounded Edge)
Dilated Splenic vein(> 9 mm)
-Homogenous, slightly hyperechoic, with mild- to-low
echogenicity compare to liver, a smooth contour.
Massive Splenomegaly
Mild irregular contour and inhomogeneous echo-structure with diffuse hyperechoic
foci suggesting small infarctions
Splenomegaly with Splenic Vein
Dilation
If the spleen is minimally enlarged, may be followed with
careful and regular observation.
Patients with enlarged spleens are more likely to have splenic
rupture from blunt abdominal or low thoracic trauma.
Splenomegaly most likely result in splenectomy
Swaoop J, O’Reily RA. Splenomegaly at a University Hospital
compared to a nearby county hospital in 317 patients. Acta
Haematol 1999;102:83-8.
Ioanitescu S, Iliescu L, Harza M, Ismail G, Copaci I. Ultrasound of
the spleen,EFSUMB Course Book;1-46. Published by
EFSUMB, 2012.
Radhakrishnan N, Besa,C, E. Splenomegaly. Medscape. 2018
January 09;1-9
World Health Organisation, World Federation for Ultrasound
in Medicine and Biology: Manual of Diagnostic ultrasound;
2003