Subject Name is BPPK one compartment open model

This is the notes for 4th year students those are studying Pharm.D and B.pharmacy as per syllabus under JNTU Hyderabad. This is the hand writing notes.

1. one Compared ment Open Model

> one compartment open Model i, the ©
the PNoCess y dreug Y,

and Elimination th the b
> The term ‘open’ mal ¡cades

the body
A Types of one Gmpastment pon Hada! :

> e0ependira upon the rate % input, Sevesal ont

Compartment model ar —
© Zrireavenous bolus administration.

(D Conlineus ódrravenone rafusion,
QD Ex tia vasculay Zero onder absosp 29

O Beta vasculan frost Orden Absoupfion,
<P .
u o IL Wis pt

*Jne Comantmen! open Hadel;
do loser bed

distribution, Absosphion, Metaboli

La the mput and output ame

unidlise ction, ana that the ag Can lo Eliminated from.

2. | Rasumphiom ¿o Tu. boty is considemee as single, |

Kinehco homogeneous unit thot has no Barre,
for the moment of dig -

QFinal distribution equilibrium. between Le plasm
amd other tbody” fluids - auained Instinct
This model 15 applied to those dus tor

distribude rapidly, Y
PS MORE alt ard out Of the Comparten

5 ebiminaton uk a ast order prow.

©_Kate of input & omeoter than Rare of output,

AD The anatomical Compartiment ıs blood L plasma

IN he or

3. + pal ace econ take a ipjeclion in eur b in
D + hxellgh Aftvavanous bolus than if! Fak one On) |
À minutes f Complete Cónculation- omg LL tog CE nn
\e7t can ollo 3 —

€ Harhemalicaf} Express 45 7
_ | Kate of due present n |

ation lo the bo
| oo Er = Rate n= eat aut. |
Since, wate by (on abremplion & absent The og uahe,
becomes — u di. cate a.

Y the role ar a pot odon &

un ouf re)
. Kem Livst biden Elimina [a Constan

RT Amout of Ag in the vod

Kinelie 449 =

4. Esti matic
LÉO
he. Lliminafren aha: can ee characterite

Y 3 parameters —
DE limina fron Kate Constant
& Elimination yy Life

Oe leavanee:

« Element 7 Rate. constaníz o .
xo 7 ulam plot # a du that. ellpros MET
comparta nt Kfooke and given pppoe vero

mure CE

> beni Ge wid
Jon the Eliminalio?
in ene cet, apartment ae
Mode/: |
eg he Elim mine
a pining LE z zu gm
|

aS)
>
+

5
encentiation — -

5. a. SOE 7 = u

© Eléminat Mate constant :

ae — 109 xo MET
ar + Et log x =109 a3
a SE —KEdt . 2
2 -kEl |
dx

1 =
= loge,
ex KE/at [ Ge "2/303 |
o

0
> Inx-Inx, = vet has. a Ks

=2 [nk = Tnxo + Kgf stepe = ._
[Ir Ho Ket | ” ae
oo wy RE= KmtKe Kp tka _

6. SOK
Sc

* Ane Un 4 5
Ls. ue TRE Zumt (DUG; a aan
is an import pharmacokinetic pasa meter estimada

by Bevexal Method.

=
re & ne arca undew à plasma dug concen nation.

Lime cure:
L Auc can be measured y vanieus Madhom adical Technigs
de Ihe most epmmon Mathematical ane —

u O) rñapescidal Helbod

u e agp

pasala nenes © Kel Method:
1 pi motor Hathod:

ny | mi
E eet and weight petho
Hefnod-

o 9) counting qua

/!
1

us >
se Felinaslion of Rate constant Kel! .
rhe (gran of M8 “plat amount YIP P+ er
which A memowd pes und me overalt elem? 109
constant
Er uation Ÿ Kel—
, u
plasma ¿encendia jon.
e

NL Rak of charges th dng
dCr/d “as
N dep/dt a

7. e ds 7

I Elimination Ja les The Elles |
'K Lge ix define a the time

WW

| Ne used fe the amount % Tem —

deg concentsation à

| oe ded bak g fe = y
mitialed valu. 5

ty = 28 LE

| AC Raraptescs Le

> Cleasance És define m-

volume wid condal-
de complet _ wemove
m he & pn Nev period Time.

Eu e
UN = Ro. f
pro Can’ be expressed > u roi. Fee
€

Rate © Eliminadion & kidne
7 Cla = Ol plasma Dry Conc.) flan M gan elevan

2 Cle, + ClH + Clothey. = Rate of

—Y 24

8. Ed
ioe

* Br
a alada
is am import pharmacokinetic: part meter estime

by beveral Method.
24 & 4e awea unden a plasma dez concen uation.

time curve

ue can be measured ty vamioas Nathomadical Tri]

The most common Mathematical 00 ~
O Thapesoïdal Melhod:
L © Kel Method»
se . @ ‚planimeter Hethoe:
> nee iy 0d
O Deut and weight meth
© count douare Hethod:

x Estimadion Rate constant Kel!
tthe gra of the tel amount f drug: lo tee
y und teme. overall elimination

cake marges

which à wemoved PU

constant
juan 4 Kl
plasma concert eatin.

Rake $ charges th
= dCp/dt
— qe

Ce.

a

y

er vo us:

be ang ee Sas
ul Gee &
TEA) fas

9. “Tape sata) Method: RE
Onrividing Oh que ints apes’ pel

© tata the anea f oach Agent an
OM Kum mation da the ara
tt wm
equation =
pue = Ye

| here —

| e és day Concentration:

— Cortes tration.

I Estimale Aue) ds neguieed
to determined Elo aval A ;

Clearance, Apparent volume of disfrisuben, rd
other phasmatokinehe parqrtefors -

oe

a.

10. ONE Compartfment open medel- Tu fafasion)

Dotrovenous Infusion : (rin)

Inmavenous Injection ee unsurtable exten ne
has tHe poten,

ey to puecipifata toda 3
Adranigge 5

TO Ease ef coter ale ag rate of infusion +> pip ini dual
jattent needs:
PD prevent treating maximum and mdmimun ‚plasma brel

JD other ‚ eleatsoyten amd. enuteients can be
ERAHNEN, admmztereed .

[model can be sepresented as follows +

prog Re. Bakes “Elimination

Era 25 ori
imfuston vate
7 The. Hate of es in amount of dteup in a bod:

u different blo Zero order Infusion R, and Fürst
öndere elimination -Kex.

SE = ho —Kex.
Integration of above eq”. ond een
X = Ro “Kee
el (" E > >0
E EA
>) cquotion O
vole = Le G- eket
Dew fe ¿nel
Var Ta, Ue )

ee La E ae ES

11. Te sentia)

At te Staak of CT heat fan
"ALL amount of drug in die |
body is euro and wed, nee
Doe © climine

De come of ane

in plasma >
Approach A consi) value

Calles

plaza org tene

Infusión capil? brium

Lu GK

| > sie =k

Des eRe
Kevd

pubstitidina Saque vol in @
C= ko ere
SL
AN o
© ales ess ¿KE
Oise ge Ket
ori tan > "hg (SE eng tek

a 12.303

12. phime to vea ess depends upon the elimination valf Los

c=6, | 4]

Holt life 7. Ro

did 7.065 achieved

! sa =
à as Sb+26 2 y5
3 Rs IS 4185 = 245
Y Cas LASA LAS 4395
Pr Bolas 43:95 $3125 = 46-895
© stg AG 174 a = 93.437
mi 0-781 48-437 +0-781 = 99-202
en
dx
Ge = hor Ke Hw
TROT KE Css Vd >
ss = Reo
pes
jos Re ]
HE.) 3
rs Em

np ne an my GA

s. ea
q Phen ebasbital — -days:
Prgtein — 2a hrs

Dr j
Ain eye rs.
Ket=cssvdl . revers

Px Lee #7]

Dis Rs ee
ie

13. e
plasma cone time profile |

mu. —
The. cquedion Hold deserei vin
fen: Un. den Biei

teaainsj anne

Helen iv dose . tv
a Kel

Mo, =
x= fe ext)

Angepremattc

a fusion drug

CE xol et y
RE se
kevd 1 ee
de pri
€ =% e ‘fusion
o 3 6
Asa A

4 elimination tee constant;

KE = Alpe Xa1303
# élimination Ya Wfez 0. eue
Fig

Fer

where T= Infusion time

Ar

= sr

14. \
»

After oral administration of a Single dose OF ou
at à given Hime y the amount of ua abse ud

temie ei actulation is zum,

Into athe sy Amneunt of

ap tie boly-and mau dues etiminadef

tthe the body.
ial r bo 4

ar, E
Pi] 0

At —>@

[Me amount of drug eliminated at ony Hme Y
gun as: €

o

gubstttution eq (A) y 0m0>
= vde + Ke Va (nvilt
% Eva o __, @
MS tolal amount of dru absorbed Inte tu aptemic
discal gm o Hatier aa!
2 = \
or = VAC + Kg a ea ©

Xp =KE va tu 0

he pta,

kevd ( Aug

vun = yá Cor ke (nee) s]
Ke Wg

15. A 2 . | à |
Ta h + Kp huc), | o

ke (AUS |
4 |
To Y ze unab sorbed a om time

7 ARA =Fı- a .
RA fi La = [52 etkefa Vez
Xx pre - Ke (avc)

Kr — [a —2)
FCaugpe

1
E ar
| Tt que Straight ep l |
B line f Sdope R Le 5
pe. - ke

41202

16. Compantmend

adminis tration > Tnfaoduction t
when anug is administered by
Essential for. des

ev Obswaption whieh ix

therapeutic lial! amd efficae

Tec nade af administercediion cam ve cxpresed
O zeno order Absesphon process

O first .o
| first - erden AbAcxphion Process

ere orders 14 ds simi
Zero orders 74 in similar ty consjond feat e, of tnfurton

Drug at |v sit 3
pa Re. BEE] > etiminatin.

ye AB ones

? combaol the. dh debian Spies

FAT orden 5
coher dia enfer fo Ala ea tn
fluo eresf ovolert absaption proces:

tr la EAS Elimination.

1 ondes

Bem Wgarithomie, Rot

ER orden

17. y Extracine babminishtien :

| Drag ad CA
ev Alte A dy sa |

De el from

Us etimination

| dy dey due

| EN M
a
integration above eq”
X= kapxo.
(Karke)

== ‘29
de

E RE = aro - ex > fp

eve ci] >6

C= kaFxo ss
coa y 0

Essgsement of Le parameter:

| diffuenhahon 4 equn @

Lo = de zug rt
Fe = xafxo A ue loo
| Ber) [+ .
| 30 = arm ee nol
ae Kae
vá (Ka Ke) uno [ “i
Fuer, „enat oe
doguiciimic form
Ke-net _ — Kat
tie ee 0
9 Kot et
Be in YS we

> _Kog — ke
ry

= Log (KY ke).

18. Pt fake)
7 { 303 pe)
> Hxa-ke) = 3.203 da (ua Ju)
hnax :
Amax = 230% Lo (x
A)
Cxa- ke)
Mx = pre
Vk
Cuan = 0237 EXo
Ve
Elimination. sente constant (ke)!
C= kar Xe a)

1

Vd (Ka-Kp)

Absesptioo nate comsteat Es):
O method q residual?
Po alex a)
C2 Ag nar

E porel

Aopastimic form

Le = ley q Kad
| qa ds

19. | ine ET xcxction data praposition wewed from urine =)

Ast

one method de non-MNvasive
A analytical technigtn: te measure plasma dng
a 4
Con E acturac
vP more

Covinent because it in volen

ARE Sensitive amatutical method
Île drug one in urine:
WT? KE, Ke

Collection Upine somps

le required determine

Ka, F conte, caleulated-

Wed:
A Sigrificant amount of. di must be exvveted
charges in the urine al

Aeart not Lens thon 2%
IP im analytical methed must be “ped fire dos Ane
‘dt
pe dra Aheuld be admimstered E 200 m/ of “oler
A shout ve

Follow, by 200 my given at ing intervals
Fer Am se next Y brs

Susine sump UT DES ccllectes foo 7 half -dife.
And more RER excreted drug,

Det _of climnation tate constant from unine data:

method are used
D Rake of! ee
0 Cigna -mines method)
O Fete Y gxcsetton: . A
Tie Rate of weinany dig excathin à directiy Corel
es Ae ik eee

20. Hu amount of aug in Ane Bie

ol

ex —o

dt

ca ; >
whence Y

Ke: Hem! ovate ewer” A constan
Mic to Fag) rer, Men vela;

=xekel |

subie eae") in ETS

ot *

ee Ke en here
Eonvere) Legal ic form > dz xp 2 Xeb

T IEY Lake xp Kee
+4 A Low
Lag Ke Xo

PM a groph Beer

amd Les dy ‘ ap
GE ie grans E ne

Intercept
= Leg ex

A a gor soa

ARDE Fhe ate robe

exe

A ng
E
= SEY ake x, ct
integration of above ea
Fu = Kexe y e)
er

(dem co pts) san

x

21. ae a eau in 0
a sx (Let) > ©
=

4 ¿net

a
> goal = ott BR
> Cu ud = a ¿E —=0

convert into Loy

Log (uta at) = Log i kek

= QT

7.303
oo
ve
MS
pa be) zart om
a
La
III