Terminologies
Intoxication:Thetransienteffectsduetorecent
substanceingestion,whichdisappearwhenthe
substanceiseliminated.
Addiction:compulsiontouseadrug,usuallyforits
psychic,ratherthantherapeutic,effects.
Tolerance: The state in which the same amount of a
drug produces a decreased effect, so that increasingly
larger doses must be administered to obtain the
effects observed with the original use.
PhysicalDependence:Thedevelopmentof
withdrawalsymptomsonceadrugisstopped.
What is a drug?
A drug is a substance that
has an action on biological
tissues when administered
Some drugs influence mood
cognition and behavior
◦Psychoactive/Psychotropic
drugs are like alcohol,
cocaine, diazepam etc.
Psychoactive Substance
Psychoactive (psychotropic) substance is any
substance which after absorption has
influence on mental processes both
cognitive and affective.
Drug Action on the Nervous System
Mostdrugsthatareabusedhaveacommon
effectonaparticularNTpathway.Thebasic
addictionpathwayinthebrainisadopamine
pathwayfollowedbyserotonin.
Activationofthispathwayaccountsforthe
positivereinforcement,feelingandmakesus
wanttorepeattheactionthattriggeredthe
feeling.
ActiononNTsystems
Agonist
Antagonist
Drug Action on the Nervous System on
Repeated Use
Tolerance
◦Decreased response to repeated exposure
Dependence
◦System adapts to presence of drug. Drug necessary
for homeostasis
Withdrawal
◦Response to drug leaving the system
Addiction
◦Compulsive engagement in reinforcing behavior
Individual-related Risk Factors
Early age of onset
Presence of early childhood behavioral
problems
Poor academic performance
Risk-taking behaviors
Favorable beliefs about substance use
Increased impulsivity
Self medication hypothesis: alcohol for
anxiety
Family-related Risk Factors
Favorable beliefs about substance use in
parents
Parental tolerance of substance use
Lack of closeness and attachment between
adolescent and parent
Lack of discipline/supervision by parent
Parental substance use
Childhood physical or sexual abuse
Peer-related Risk Factors
Peer substance use
Favorable peer attitudes to use
Greater orientation of adolescents to peers as
opposed to parents
Community-related Risk Factors
◦Low Socio economic status
◦High population density
◦High crime rate
◦Easy availability of drugs
Alcohol: Our Most Primitive Intoxicant
Egypt
◦Barleybeerisprobablytheoldestdrinkinthe
worldwithitsorigininEgyptpriorto4200
BC
China
◦7000BC-theproductionofaprehistoric
mixedfermentedbeverageofrice,honeyand
fruit
◦2000BC-uniquecerealbeverages(Shangand
WesternZhouDynasties)
1.Simple withdrawal symptoms
◦The most common withdrawal syndrome is a
hangover on the next morning
◦Mild Tremor
◦Anxiety
◦Increased heart rate and blood pressure
◦Sweating
◦Nausea, vomiting
◦Insomnia
◦Weakness
◦Impaired attention
◦Irritability
Alcohol intoxication Alcohol withdrawal syndrome
Itoccursasaresulttheamountofalcoholinbloodstream
increases.Thehigherthebloodalcoholconcentrationis,themore
impaired.
Symptomsincude;
Inappropriate behavior,
unstable moods,
Impaired judgment,
Impaired attention.
Slurred speech,
Impaired attention or memory.
Poor coordination.
Aggression.
Labilityof mood.
Unsteady gait.
Difficulty standing.
Nystagmus.
"Blackouts," where person don't remember any events
during intoxicated period.
Decreased level of consciousness (e.g. stupor, coma).
Very high blood alcohol levels can lead to coma or even
death.
Acute alcohol intoxication when severe may be
accompanied by hypotension, hypothermia and Depression
of the gag reflex.
Itcanoccurwhenalcoholusehasbeenheavyandprolonged
andisthenstoppedorgreatlyreduced.Itcanoccurwithin
severalhourstofourorfivedayslater.
Symptomsinclude;
Sweating,rapidheartbeat,handtremors.
Problemssleeping(insomnia).
Highbloodpressure
Nauseaandvomiting.
Hallucinations.
Restlessnessandagitation.
Anxiety,andoccasionallyseizures.
Symptomscanbesevereenoughtoimpairabilitytofunction
atworkorinsocialsituations.
(Above symptoms are more noticeable when person wake up
with less alcohol in blood.)
The most severe type of withdrawal syndrome is known as
delirium tremens (DT). Its signs and symptoms include:
-Extreme confusion.
-Extreme agitation.
-High Fever.
-Seizures (Grand mal convulsions)
-Tactile hallucinations, such as having a sense of
itching or burning that isn’t actually occurring.
-Auditory hallucinations or hearing sounds that
don’t exist.
-Visual hallucinations, or seeing images that don’t
exist
Diagnosis
Thorough history
MSE
Physical Examination
Blood examination
LFT
Nutritional test
Chest radiography etc
TREATMENT
ALCOHOL USE DISORDER
(Alcohol Abuse And Dependence)
ALCOHOL DETERRENT THERAPY
Deterrentagentsarethosewhicharegivento
desensitizetheindividualtotheeffectsofalcohol
andmaintainabstinence.Themostcommonly
useddrugisDisulfiramorAntabuse.
Antabuse(disulfiram)blocksanenzymethatis
involvedinmetabolizingalcoholintake.
Disulfiramproducesveryunpleasantsideeffects
whencombinedwithalcoholinthebody.
Medication Target Year Approved
Disulfiram Aldehyde
Dehydrogenase
1949
Research from animal models over the past 25 years has
provided promising targets for pharmacotherapy
Naltrexone Mu Opioid Receptor 1994
Acamprosate Glutamate and GABA-
Related
2004
Naltrexone Depot Mu Opioid Receptor 2006
FDA ApprovedMedications for Treating
Alcohol Dependence
PREVENTION
Preventive programs: teach adolescents how
to resist social pressure to use drugs.
Detoxification: substance specific
Drug rehabilitation: develop new coping
skills
Self-help groups: alcoholics anonymous
Disulfiram
Naltrexone
methadone
Nursing Care Plan
NursingcareplanforAlcoholrelateddisorder
Nursingdiagnosis:RiskforineffectiveBreathingPatternrelatedtodirect
effectofalcoholtoxicityonrespiratorycentreandsedativedrugsgivento
decreasealcoholwithdrawalsymptoms
OutcomeIdentificationNursingIntervention
Client will be able to:
-Maintain
Effective
Breathing
PatternWith
Respiratory
RateWithin
NormalRange,
Monitor respiratory rate/depth and pattern. Note for
periods of apnea, Cheyne-Stokes respirations.
Auscultate for breath sounds. Note presence of
adventitious sounds (e.g., rhonchi, wheezes).
Elevate head end of the bed.
Encourage deep-breathing coughing exercises.
Change positions frequently.
Keep suction equipment, airways ready.
Administer supplemental oxygen if needed.
Review serial chest x-rays, arterial blood gases
(ABGs)/pulse oximetryas indicated.
Nursingdiagnosis:RiskforInjuryrelatedtoCessationofalcoholand
appearanceofwithdrawalsymptoms,Involuntaryclonic/tonicmuscleactivity
(seizures),reducedmuscleandhand/eyecoordination.
Outcome IdentificationNursing Intervention
Client will be able to:
-Demonstrate
absence of
untoward
effects of
withdrawal.
-Experienceno
physicalinjury.
Monitor for withdrawal symptoms.
Monitor/document seizure activity.
Maintain patent airway.
Provide safety to the patient (e.g., padded side
rails, bed in low position).
Assess for gait.
Palpate upper arm to conform actual
withdrawal versus medication-seeking
behavior.
Assist patient in ambulation and self-care
activities as needed.
Administer medications as indicated e.g.:
Benzodiazepines (BZDs)
Nursingdiagnosis:AnxietyorFearrelatedtophysiologicwithdrawal,
Situationalcrisis(hospitalization)andperceivedthreatofdeathasevidencedby
feelingsofinadequacy,shame,increasedhelplessness/hopelessnessandincreased
tension.
Outcome IdentificationNursing Intervention
Clientwillbeableto:
-Verbalize
reductionof
fear and
anxiety.
-Demonstrate
problem-
solvingskills
and use
resources
effectively.
Identifycauseofanxiety.
Explainthatalcoholwithdrawalusuallyincreases
anxietyanduneasiness.
Reassesslevelofanxietyonanongoingbasis.
Developatrustingrelationshipwithpatientthrough
frequentcontactbeinghonestandnonjudgmental.
Showanacceptingattitudeaboutalcoholism.
Reorientfrequently.
Administermedicationsasindicated,e.g.:BDZs(e.g.,
chlordiazepoxide[Librium],diazepam[Valium]).
ReferralpatientforDetoxificationandcrisiscentre.