Definition of SSI
The CDC : =< 30 days of
surgery (or within a year in
the case of implants)
Mangram . Guideline for prevention of surgical
site infection, 1999. Infect Control Hosp Epidemiol 1999;
classificationincisional
surgical site infections
Superficial
Deep
Organ/space
superficial incisional
surgical site infections
< 30 days of procedure
involve only the skin or
subcutaneous tissue around
the incision.
Mangram . Guideline for prevention of surgical
site infection, 1999. Infect Control Hosp Epidemiol 1999
Deep incisional surgical
site infections
< 30 days of procedure (or one
year in the case of implants)
are related to the procedure
involve deep soft tissues, such
as the fascia and muscles.
Mangram . Guideline for prevention of surgical
site infection, 1999. Infect Control Hosp Epidemiol 1999
ASEPSIS WOUND
SCORING SYSTEM
[ Wilson AP, Lancet1986
Southampton wound
scoring system
[Bailey IS, BMJ1992; 304: 469-71
Factors influencing SSIs
Surgical Risk Factors
Type of procedure
Degree of contamination
Duration of operation
Urgency of operation
skin preparation
operating room environment
Antibiotic prophylaxis
EWMAJournal 2005; 5(2): 11-15.
Wound class Definition Example Infection
rate (%)
Clean Nontraumatic, elective
surgery. GI tract,
respiratory tract, GU tract
not entered
Mastectomy
Vascular
Hernias
2%
Clean-
contaminated
Respiratory, GI, GU tract
entered with minimal
contamination
Gastrectomy
Hysterectomy
< 10%
Contaminated Open, fresh, traumatic
wounds, uncontrolled
spillage, minor break in
sterile technique
Rupture appy
Emergent
bowel resect.
20%
Dirty Open, traumatic, dirty
wounds; traumatic
perforation of hollow
viscus, frank pus in the
field
Intestinal
fistula
resection
28-70% Berard F, Gandon J, Ann Surg1964
Reduce hemoglobin A1c levels
to <7% before operation
Evidence
Class II data
References
Anderson DJ, Kaye KS, Classen D, et
al. Strategies to prevent surgical site
infections in acute care hospitals.
Infect Control Hosp Epidemiol 2008;
Smoking cessation 30 d
before operation
Evidence
Class II data
References
Anderson DJ, Kaye KS, Classen D, et
al. Strategies to prevent surgical site
infections in acute care hospitals.
Infect Control Hosp Epidemiol 2008
Remove hair only if it will interfere with
the operation; hair removal by clipping
immediately before the operation or
with depilatories; no pre-or
perioperative shaving of surgical
Evidence
Class I data
References
Kjønniksen I. Preoperative hair removal–
a systematic literature review. AORN J
2002
Use an antiseptic surgical scrub
or alcohol-based hand antiseptic
for preoperative cleansing of the
operative team members’ hands
and forearms
Evidence
Class II data
References
Anderson DJ. Strategies to prevent
surgical site
infections in acute care hospitals.
Infect Control Hosp Epidemiol 2008;
Prepare the skin around the
operative site with an appropriate
antiseptic agent, including
preparations based on alcohol,
chlorhexidine, or iodine/iodophors
Evidence
Class II data
References
Anderson . Strategies to prevent
surgical site
infections in acute care hospitals.
Infect Control Hosp Epidemiol 2008;
Administer prophylactic antibiotics
for most clean-contaminated and
contaminated procedures, and
selected clean procedures use
antibiotics appropriate for the
potential pathogens
Evidence
Strong Class I data
References
Springer R. The Surgical care
improvement project-focusing on infection
control.Plast Surg Nurs 2007;
Administer prophylactic antibiotics within
1 h before incision (2 h for vancomycin
and fluoroquinolones)
Evidence
Strong Class II data
References
Springer R. The Surgical care
improvement project-focusing on
infection control.Plast Surg Nurs
2007
Use higher dosages of
prophylactic antibiotics
for morbidly obese patients
Evidence
Limited Class II data
References
Springer R. The Surgical care
improvement project-focusing on
infection control.Plast Surg Nurs
2007
Carefully handle tissue, eradicate dead
space, and adhere to standard principles
of asepsis
Evidence
Class III
References
Anderson DJ. Strategies to prevent
surgical site infections in acute care
hospitals. Infect Control Hosp
Epidemiol 2008;
Redose prophylactic antibiotics with
short half-lives intraoperatively if
operation is prolonged (for cefazolin if
operation is >3 h) or if there is
extensive blood loss
Evidence
Limited Class I, Class II data
References
Scher K. Studies on the duration of
antibiotic administration for surgical
prophylaxis Am Surg 1997
Maintain intraoperative
normothermia
Evidence
Class I; some contradictory Class II
data
References
Sessler DI, Akca O.
Nonpharmacological prevention of
surgical wound infections.
Clin Infect Dis 2002
Discontinue prophylactic
antibiotics within 24 h after the
procedure (48 h for cardiac surgery
&liver transplant procedures)
discontinue prophylactic
antibiotics after skin closure
Evidence
Class I;
meta-analyses support single dose
regimens for prophylaxis
References ASHP Therapeutic guidelines on antimicrobial
prophylaxis in surgery. Am J Health Syst Pharm 1999
Maintain serum glucose
levels <200 mg/dL on PO
Evidence
Class II data
References
Anderson DJ. Strategies to prevent
surgical site infections in acute care
hospitals. Infect Control Hosp
Epidemiol 2008
Monitor wound for the
development of SSI
postoperative days 1 and 2d
Evidence
Class III data
References
Anderson DJ. Strategies to prevent
surgical site infections in acute care
hospitals. Infect Control Hosp
Epidemiol 2008
•opening the wound I&D .
•For most patients who have had their
wounds opened and adequately
drained, antibiotic therapy is unnecessary.
Treatment of SSI
Stevens DL. Prguidelines for the diagnosis and management of skin and soft-tissue
infections. Clin Infect Dis 2005actice
o use antibioticsonly when there are
significant systemic signs of infection
(temperature higher than
38.5Cor heart rate greater than 100
beats/min)
erythema extends more than 5 cm
from the incision.
Stevens DL. Prguidelines for the diagnosis and management of skin and
soft-tissue infections. Clin Infect Dis 2005actice
Treatment of SSI