Suspension By Deepak Kumar assistant professor

lecture presented by Deepak Kumar
also available on YouTube
https://youtu.be/jNgaOOkDLJ4

1. TOPIC –
SUSPENSIONS
PHARMACEUTICS –I

2. SUSPENSIONS
Definition
¡PharmaceuticalSuspension
APharmaceuticalsuspensionisadispersion
inwhichtheActivePharmaceutical
Ingredient(internalphase)isdispersedin
thevehicle(externalphase).

4. Asperthisdefinition,thesolubilityofthetherapeuticagent
inthevehicleislow.
Theinternalphaseconsistsofinsolubleorpoorlysolublesolid
particles.
Theseparticlesinthesizerangefrom0.5-5µthatis
maintainedconsistentlythroughoutthesuspendingmedium
withtheaidofasingle/combinationofthesuspendingagent.
Theexternalphase(suspendingmedium)isgenerallyaqueous
insomeinstances.Itmaybeanorganicoroilyliquidfornon-
oraluse.

5. The reasons to formulate a
pharmaceutical suspension:
*Ifthedrugisinsolubleorpoorly
solubleinthedeliveryvehicle.
*Tomaskthebitterorunpleasant
tasteofthedrug.
*Toincreasethestabilityofthedrug.
*Toachieveasustainedorcontrolled
drugrelease.

6. Examples of Pharmaceutical
Suspensions
Antacidoralsuspensions
Antibacterialoralsuspension
Drypowders(antibiotic)for
oralsuspension

7. -Analgesic oral
suspension
-Anthelmenticoral
suspension
-Anticonvulsant oral
suspension
-Antifungal oral
suspension

8. Classification -
-Based on General Classes
-Based on the Proportion of Solid
Particles
-Based on Electro-kinetic Nature of
Solid Particles
-Based on Size of Solid Particles

9. Based on General Classes
·Oral suspension–e.g. Antacids,
Paracetamol suspension, and Tetracycline
hydrochloride.
·Externally applied suspension-e.g.
Calamine lotion.
·Parenteral suspension -e.g. Procaine
penicillin G, Insulin Zinc Suspension.

10. Based on the Proportion of Solid
Particles
·Dilute suspension (2-10%w/v solid)-
e.g. Cortisone acetate, Prednisolone
acetate.
·Concentrated suspension (50%w/v
solid) -e.g. Zinc oxide suspension.

11. Based on Electro-kinetic Nature
of Solid Particles
· Flocculated suspension
· Deflocculated suspension

12. Based on Size of Solid Particles
Colloidal suspensions -Particle sizes of suspended solid
less than about 1 micron in size.
Coarse suspensions -Particle sizes of greater than
about 1micron in diameter.
Nano-suspensions -Biphasic colloidal dispersions of
Nano-sized drug particles stabilized by surfactants.

13. Advantages
&
Disadvantages

14. AdvantagesofPharmaceuticalSuspension
ItenhancesthechemicalstabilityofsomedrugslikeProcainepenicillinG.
Therapeuticagentspresentinthesuspensiongivesahigherbioavailabilityrateas
comparedtootherdosageforms.Solution>Suspension>Capsule>CompressedTablet>
Coatedtablet.
DurationandtheonsetofactioncanbecontrolledlikeProtamineZinc-Insulinsuspension.
ItcanmasktheunpleasantorbittertasteoftherapeuticagentslikeChloramphenicol.
Pharmaceuticalsuspensionsareausefuldrugdeliverysystemfordrugsthathavealow
solubility.

15. Pharmaceuticalsuspensionsmaybeemployedto
administerdrugstopatientswhohavedifficultyin
swallowingofsolid-dosageforms.
Pharmaceuticalsuspensionsmaybeformulatedto
providecontrolleddrugdelivery,e.g.as
intramuscularinjections.

16. Disadvantages of Pharmaceutical Suspension
Physical stability, sedimentation, and compactioncan cause some troubles.
It is bulky sufficient care must be taken during handling and transportand therefore
difficult for a patient to carry.
It is difficult to formulate.
Uniform and accurate dose of the therapeutic agentcannot be obtained unless it
packed in the unit dosage form.
Pharmaceutical suspensions are essentially unstable. Hence, it requires formulation
skill to ensure the physical stability of the formulation is retained over the period of
the shelf-life.
The formulation of anesthetic suspension is difficult.

17. Applications
A suspension is usually suitable for poorly soluble or insoluble drugs E.g.
Prednisolone suspension.
To prevent drug degradation or to improve the drug stability. E.g. Oxytetracycline
suspension.
To mask the bitter or unpleasant taste of the drug. e.g. Chloramphenicol
palmitate suspension.
It can be formulated for topical application e.g. Calamine lotion.
Vaccines are often formulated as a suspension. e.g. Cholera vaccine.

18. Features expected in Pharmaceutical suspensions
It should have a low rate of sedimentation it means suspended particles should not
settle rapidly.
It should be easy to pour.
It should have good syringeability.
It should be physically, chemically, and microbiologically stable.
In case of parenteral or ophthalmic, it should be sterilizable.
The disperse phase must be easily redispersed with gentle shaking.
The flow properties of the suspension should be such that the formulation to be easily
removed from the container.
It should be aesthetically pleasing.

19. Flocculatedsuspension:-
➤Inthistype,solidparticlesarelooselyaggregates
themselves,meansindividualparticlesarecomein
contactwitheachothertoformsnetworklikestructure
calledasafloccules.
➤Theseflocsarelight,fluffyinnature.
➤Aggregationisachievedbyaddingflocculatingagent.
➤Thissuspensionwillreadilysediments.
➤Thissuspensionpossesbetterphysicalstabilitybutless
bioavailabilityascomparedtodeflocculatedsuspension
duetodissolutionoffloccules.

20. Deflocculated suspension
➤In this type of suspension, individual particle exits as a
separate entity. Hence particles approaches each other,
they experience repulsive forces. This force create a high
potential barrier, which prevents a aggregation of particles.
➤During storage, these suspension shows a sedimentation at
slow rate, due to that particles forms a close packing
arrangement.

21. ➤So that it is difficult to re dispersed
on agitation & forms a cake or
claying which is hard in nature.
➤This type of suspension have
shorter shelf life but high
bioavailability as compared to
flocculated suspension.

22. Difference between flocculated & deflocculated suspension
Flocculated suspension
1. Particles form loose aggregate & form a
network like structure
2. Rate of sedimentation is very high
3. Sediment is rapidly formed
4. Sediment is loosely packed & does not form a
hard cake
5. It is easy to redisperse
Deflocculated suspension
1. Particle exist as separate entities
2. Rate of sedimentation is very low
3. Sediment is slowly formed
4. Sediment is closely packed & a hard cake
is formed.
5. Difficult to redisperse

23. 6. Not pleasing in appearance
7. Floccules stick to the side of bottle
8. Less bioavailability
9. High shelf life
6. Pleasing in appearance
7. Floccules do not stick to the side of
bottle
8. High bioavailability
9. low shelf life

24. 4. Suspending Agent –
A –Natural -Acacia, Tragacant, Alginates.
B –Semi -Synthetic -Methyl cellulose,
Microcrystalline cellulose.
C –Synthetic –Carbomers / Carbopol, Colloidal
silicon dioxide
5. Organoleptic Agents –
A –Coloring Agent-
B –Flavoring Agent-
C –Sweetening Agent-

25. Formulation :-
1. Medicament / Drug
2. Flocculating agent-
A –Electrolytes –sodium phosphate, citrates
B –Surfactant -ionic and nonionic
C –Polymers –Starch, Cellulose, Tragacanth,
Carbomer.
3. Deflocculating agent –Polyphosphates, lignophosphates, and
water soluble synthetic polymer.

26. Evaluation :-
1. Physically –
Sedimentation rate
Flocculation, Caking, Color, Taste, Visual
inspection, Particle size, Clarity, Homogeneity,
Viscosity

27. 2. Chemically:-
pH, Mixing / % of assay, Dissolution Rate,
3. Microbiologically:-
Microbial limit, preservative efficacy
Bacteria, yeast, fungi, etc

28. Method to overcome stability problems
1.–Use stabilizer –Gums, Polymers.
Adjusting particle size
Increase viscosity
Using anti settling agent –silica
Homogenization

29. 2. –Use antioxidants –like Vit. –E
pH adjuster / Buffers
Use preservative / Antimicrobial agent –
Methyl paraben, Propyl paraben.
Control of storage condition –Temperature
control, light protection (amber colored bottle),
Humidity control.
3. –Sterilization ( By heat –dry / moist)
4. –Formulation / process optimization
5. –Container and closure selection.

31. What is the primary advantage of
suspensions in pharmaceutical
formulations?
A. Rapid absorption in the gastrointestinal tract
B. Extended shelf life
C. Easy preparation
D. High solubility
MCQS QUESTION :-

32. Which of the following is a
disadvantage of using suspensions
in pharmaceuticals?
A. Limited stability
B. Rapid absorption
C. High clarity
D. Low viscosity

33. Which of the following is an
advantage of suspensions?
A. Suspensions are easy to prepare.
B. Suspensions are stable.
C. Suspensions are easy to administer.
D. All of the above.

34. Which of the following is a disadvantage of
suspensions?
A.Suspensions can settle out over time.
B. Suspensions can be difficult to filter.
C. Suspensions can be difficult to sterilize.
D. All of the above.

35. Which of the following is a
suspending agent used in oral
suspensions?
A. Methylcellulose
B. Xanthan gum
C. Bentonite
D. All of the above

36. Which of the following is a preservative used in
suspensions?
A. Sodium benzoate
B. Methylparaben
C. Propylparaben
D. All of the above

37. Which of the following is a type of
suspension that is used in
pharmaceuticals?
A. Oral suspension
B. Topical suspension
C. Injectable suspension
D. All of the above

38. Suspension is a
a)one phase system
b)two phase system
c)multiple phase system
d)all of these

39. Which of the following is an
example of oral suspension?
a)Paracetamol suspension
b)Calamine Lotion
c)Procaine penicillin G suspension
d)All of these

40. Choose the correct order of bio availability in the following
dosage forms.
a)Suspension > Solution > Capsule > Compressed Tablet > Coated tablet
b)Solution > Suspension > Coated tablet > Compressed Tablet > Capsule
c)Solution > Suspension > Capsule > Compressed Tablet > Coated tablet
d)Solution > Coated tablet > Capsule > Compressed Tablet > Suspension

41. Thank
you