Tabletting different components and manufacturing technologies

Tabletting

1. Tabletting Dr Asim Sajid 17 October 2023 17 October 2023 TABLETTING 1

2. Learning Outcomes At the end of this session, you should be able to: Define the concept of tabletting in pharmaceuticals Understand the key components in tablet formulations Explain the tablet manufacturing process Identify common issues in tablet production Demonstrate knowledge of tablet quality control 17 October 2023 TABLETTING 2

3. Why do we make tablets? 17 October 2023 TABLETTING 3

4. Tablet Components 17 October 2023 TABLETTING 4

5. Tablet Components 17 October 2023 TABLETTING 5 API Fillers Binders Disintegrants Lubricants

6. Tablet Components Drug (API) Fillers (Diluents) Add bulk Uniform dosage Increase size for volume/weight Lactose/MCC Binders (Adhesives/Granulating agents) Cohesion (maintain structure) Tablet hardness Starch/PVP/HPC 17 October 2023 TABLETTING 6

7. Tablet Components Disintegrants Promote disintegration into smaller particles Aid dissolution Enhance bioavailability Croscarmellose sodium Lubricants Ease of manufacturing by reduce friction Uniformity (weight and dimension) Magnesium stearate, sodium lauryl sulphate 17 October 2023 TABLETTING 7

8. Tablet Formulation What factors do we need to consider when selecting excipients? 17 October 2023 TABLETTING 8

9. Manufacturing Process Granulation – improve powder flowability Dry granulation Wet granulation Compression – tablet press Influences hardness Coating Films, sugar, controlled release Challenges 17 October 2023 TABLETTING 9

10. Common Issues Capping Shaped dome tears away Lamination Separation into horizontal layers Chipping Breakage at edges, small chips/fragments Mottling Uneven distribution of colour 17 October 2023 TABLETTING 10

11. Quality Control Weight variation Hardness testing Friability testing Disintegration tests Meet pharmacopeia standards 17 October 2023 TABLETTING 11

12. Quiz 1 Which component is responsible for binding the tablet ingredients together? a) API b) Excipient c) Binder d) Diluent 17 October 2023 POWERPOINT PRESENTATION TEMPLATE BLUE 12

13. What are excipients? 17 October 2023 POWERPOINT PRESENTATION TEMPLATE BLUE 13

14. Pharmaceutical Excipients 17 October 2023 POWERPOINT PRESENTATION TEMPLATE BLUE 14

15. 17 October 2023 POWERPOINT PRESENTATION TEMPLATE BLUE 15