Takotsubo cardiomyopathy ( The broken heart syndrome ).pdf

Takotsubo cardiomyopathy , also known as broken heart syndrome , is an acute heart condition that closely mimics acute coronary syndromes. It is seen primarily in postmenopausal females.

Read this presentation to learn about this condition more..

1. TAKOTSUBO CARDIOMYOPATHY
Left
Ventricle
Enlarged
Left
Ventricle

3. PATHOPHYSIOLOGY
Phase 1 involves activation of the hypothalamic–pituitary–adrenal axis,
and phase 2 involves myocardial dysfunction induced by sympathetic
hyperactivity.

The first phase begins after an acute psychological and/or physical stress
resulting in increased circulating and myocardial catecholamine levels.
During the second phase, different mechanisms have been considered to
explain the cardiotoxicity of catecholamines producing myocardial
dysfunction. Among these, the most prominent are direct
catecholamine-mediated myocardial stunning and microvascular spasm

4. PATHOPHYSIOLOGY

5. TYPES
Diagram representing the five types of Takotsubo syndrome based on left ventricular
angiograms:
I, apical type, the typical and most common variant;
II, midventricular atypical variant;
III, basal atypical variant;
IV, focal atypical variant; and
V, isolated right ventricular or biventricular variant