Tema 02_Respuesta Inmunitaria a Parásitos.pdf

Parasitos

1. Medicina Humana
MSc. Blgo. Richard Zapata-Dongo
Inmune Response to
Parasites
Protozoos and Helminths

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Let's study the following case of parasitosis

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Amebiasis, diarrhea, abdominal pain

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MicroscopicStudy
1000x

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E. histolyticcyst
Referential diagram Seen under a light microscope Lugol coloration

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TrophozoiteofE. histolytic

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Life cycle of E. histolytic
Cyst
Trophozoite

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E. Histolytic can invade multiple tissues

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E. Histolytic attacks the layers of the digestive mucosa
E. Histolítica
Invasion
Microbiota
Protected
Tissue
Dysbiosis
Infestation
ImmuneResponse
E. Histolítica
Invasion

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Immune
response against
histolytic E.
Defense cell

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ImmuneSystem: Overview

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TheImmuneResponse
INNATE
INMUNITY
ADAPTIVE
INMUNITY
Rapid Response SlowResponse

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Cellsand OrgansofImmuneSystem

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Themagicrole ofbonemarrowin hematopoieticontogeny

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Innate Response
Neutrophils Macrophages
Dendriticcells
(DCs)
Phagocytosis

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PathogenRecognition
Receptor Examples Ligand
Patternrecognition
receptor
TLR
MANNOSE or CD 206
receptor
Dectina1
CD14
Amongothers, LPS,
lipotheicacid
Flagellin
Mannose
B1-3 Glucan
LPS bindingprotein
Acetyl-LDL
Opsonicreceptors FcyRS
FcaRICD89
CR1 CD35
CR3, CR4
IgG
IgA, IgA2
Lectinassociatedwith
mannose,
C1q, C4b
ApoptoticbodyreceptorsTIM-1, TIM-4, BAI1,
Estabilina-2, Mer, Axl,
Tyro3, CD36, CD68
Fosfatidilserina,
Gas6,ProteinaS,
MFG-38

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PAMPs
PRR
L. infantum
S. mansoni
Leishmaniaspp

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Phagocytosis

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DendriticCells: AntigenPresentingCells

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Neutrophil
Diapedesis

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Pathogenrecognitionexample: Malaria infestation

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Adaptative Response

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B and T cellReceptor

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Plasma cells: Productionofantibodies

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Immunoglobulines

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FuntionofImmunoglobulines

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ComplementSystem

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Immuneresponse toparasites examples

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Acuteness and chronicity of helminth infection drive distinct immune profiles
10.12688/F1000RESEARCH.15596.1

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IMMUNE RESPONSE AGAINST HELMINTHS
https://www.frontiersin.org/articles/10.3389/fimmu.2014.00433/full

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Role of basophils in protective immunity to parasitic infections
https://link.springer.com/content/pdf/10.1007/s00281-016-0563-3.pdf

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ImmunopathogenesisofIntestinal ProtozoalPathogens
https://www.sciencedirect.com/science/article/pii/B9780702068966000302?via%3Dihub

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Conclusions

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Conclusions
▪It is important to know the principles of immunology to understand
the pathogenesis caused by a pathogenic agent.
▪It is important to know the constitutive, innate and adaptive
immune responses.
▪Each pathogen awakens a different response.

35. Medicina Humana
MSc. Blgo. Richard Zapata-Dongo
Inmune Response to
Parasites
Protozoos and Helminths