Thrombolysis

Thrombolysis- Removal of harmful blood clots.

1. THROMBOLYSIS By: Sachin Kumar M- Pharm (Pharmacology) Dept. of pharma . Sci. M.D.U Rohtak , Haryana

2. CONTENTS INTRODUCTION USE of THROMBOLYSIS BLOOD CLOT CAUSES and RISK FACTORS of BLOOD CLOT DIAGNOSIS of BLOOD CLOT THROMBOLYTIC AGENTS REFERENCES

3. INTRODUCTION Thrombolysis also known as thrombolytic therapy . It is a treatment to dissolve dangerous blood clot in blood vessels, improve blood flow and prevent damage to tissues and organ. Formation of blood clot inside a blood vessel obstructing the blood flow through the circulatory system.

4. USE OF THROMBOLYSIS In Deep Vein Thrombosis (DVT) In Pulmonary Embolus In Stroke In Heart Attack In Mesenteric Ischemia

5. DEEP VEIN THROMBOSIS

6. STROKE

7. PULMONARY EMBOLUS

8. ARTERIAL BLOOD CLOT IN LEGS

9. MESENTRIC ISCHEMIA

10. BLOOD CLOT

11. CAUSES of BLOOD CLOTS Damage of blood vessels Excessive clotting ability ( Hypercoagulability ) Pooling of blood (Stasis) Inherited causes of blood clot - Increase level of procoagulants - Decreased level of anticoagulants - Abnormal fibrinolysis

12. DIAGNOSIS of BLOOD CLOT ULTRASOUND VENOGRAPHY D-DIMER TEST CT- SCAN VENTILLATION PERFUSION

13. THROMBOLYTIC AGENTS STREPTOKINASE UROKINASE TPA (TISSUE PLASMINOGEN ACTIVATORS) - Ateplase - Reteplase - Tenecteplase ANTICOAGULANTS DRUGS

14. ANTICOAGULANTS DRUG NOVAL DRUGS - Apixoban - Rivaroxaban - Endoxaban - Abigatran HEPARIN WARFARIN

15. REFERENCES Fauci , Anthony S., et al.  Harrison's Principles of Internal Medicine . 17th ed. United States: McGraw-Hill Professional, 2011.   Katzung , Bertram G., Susan B. Masters, and Anthony J. Trevor, “ Basic & clinical  pharmacology ”, Eleventh edition, Published by MC Graw Hill - 12 Aug 2009, Page no.- 587-602. Heit , JA. The epidemiology of venous  thromboembolism  in the community.  Arterioscler   Thromb   Vasc   Biol 2008;28:370­372.   Weitz  JI. Diagnosis of Deep Venous Thrombosis and Pulmonary Embolism.  http://www.surgeongeneral.gov/topics/deepvein/workshop/agenda.html . Accessed March 10, 2010.  Hirsh J, et al. Mechanism of action and pharmacology of  unfractionated  heparin.  Arterioscler   Thromb   Vasc  Biol. 2001;21:1094­1096.