thyroiditis ent in neck throat swelling .pptx

ent

1. Thyroiditis Hashimoto thyroiditis De- quervain thyroiditis Acute thyroiditis Riedel thyroiditis

2. Thyroiditis Inflammation of the thyroid gland Acute illness Severe thyroid pain Manifested primarily by thyroid dysfunction

3. Types Acute ( Suppurative ) Thyroiditis Streptococcus and anaerobes (70% Escherichia coli, Pseudomonas aeruginosa, Haemophilus influenzae , Eikenella corrodens , Corynebacterium, Coccidiomycosis species More common in children Diagnosis : leukocytosis on blood tests and FNA biopsy for Gram's stain, culture, and cytology Treatment : parenteral antibiotics and drainage of abscesses Subacute Thyroiditis Painful or painless Post viral inflammatory response, Genetic predisposition, autoimmune TSH is decreased, and thyroglobulin, T 4 and T 3 levels are elevated beta blockers and thyroid hormone replacement (after hyperthyroid phase) Surgery for recurrent attacks Chronic Thyroiditis Hashimoto’s Reidel’s De- quervain’s

4. Hashimoto Thyroiditis First described by hashimoto , in 1912, as struma lymphomatosa — Transformation of thyroid tissue to lymphoid tissue Most common inflammatory disorder of the thyroid Leading cause of hypothyroidism

5. Etiology Autoimmune process Increased intake of iodine Medications: interferon, lithium, and amiodarone Inherited predisposition Chromosomal abnormalities : turner's syndrome and down syndrome. Associations with hla-b8, dr3, and dr5 haplotypes

6. Pathogenesis Activation of CD4+T (helper) lymphocytes T cells recruit cytotoxic CD8+T cells to the thyroid. Hypothyroidism results from: destruction of thyrocytes by cytotoxic t cells autoantibodies, which lead to complement fixation and killing by natural killer cells or block the TSH receptor Antibodies are directed against the three main antigens Tg (60%) TPO (95%) TSH-R (60%) sodium/iodine symporter (25%) Apoptosis (programmed cell death) also implicated

7. Pathology Gland is diffusely infiltrated by small lymphocytes and plasma cells, occasionally shows well-developed germinal centers Thyroid follicles are smaller than normal with reduced amounts of colloid and increased interstitial connective tissue Follicles are lined by hürthle or askanazy cells , which are characterized by abundant eosinophilic, granular cytoplasm.

8. Clinical Presentation Male: female ratio 1:10 to 20) Ages of 30 and 50 years. Minimally or moderately enlarged firm gland 20% of patients present with hypothyroidism 5% present with hyperthyroidism ( hashitoxicosis)

9. Diagnostic Studies TSH T 4 and T 3 levels Thyroid autoantibodies FNA biopsy if solitary suspicious nodule or a rapidly enlarging goiter

10. Treatment Overtly hypothyroid: Thyroid hormone replacement therapy Subclinical hypothyroidism: Male patients TSH greater than 10 mu/L Euthyroid patients to shrink large goiters Surgery may occasionally be indicated for suspicion of malignancy or for goiters causing compressive symptoms or cosmetic deformity

11. Complications of hashimoto Overt hypothyroidism Goitre Rarely cancer thyroid lymphoma Compresssive symptoms Heart diseases n neurological manifestations

12. De Quervain’s thyroiditis First described in 1904 Granulomatous thyroiditis Viral infections: Adenovirus, Coxsackievirus , Influenza virus, Epstein barr virus, Mumps, Echovirus & Enterovirus Less common than Hashimoto's thyroiditis Gland swells up is very painful and tender Patient becomes hyperthyroid but the gland cannot take up iodine so the radioactive iodine uptake is very low

13. Absence of thyroid antibodies differentiates this condition from autoimmune thyroiditis Recovery is invariably complete and response to prednisolone is so dramatic that it is almost diagnostic

14. Facts of de quervain thyroditis a/k/a sub acute thyroiditis Abs absent and ESR is raised. Resembles infectious but no agent has been identified thus no ole of antibiotics. Few pts develop hypothyroidism.

15. Riedel's Thyroiditis Riedel's struma or invasive fibrous thyroiditis Replacement of all or part of the thyroid parenchyma by fibrous tissue Etiology : Autoimmune diseases, such as pernicious anemia and graves' disease Mediastinal, retroperitoneal, periorbital, and retro-orbital fibrosis Sclerosing cholangitis Women between the ages of 30 and 60 years .

16. Presentation: Painless, hard anterior neck mass Dysphagia Dyspnea Choking Hoarseness Symptoms of hypothyroidism & hypoparathyroidism Hard, "woody" thyroid gland Diagnosis: Open thyroid biopsy Treatment: Surgery Thyroid hormone replacement Corticosteroids and tamoxifen

17. An isolated nodule in the thyroid gland Solitary Thyroid Nodule Benign: Cysts Adenoma- Papillary Follicular Hurthle cell type Toxic Adenoma- solitary hyper-functioning thyroid nodule Non toxic Adenoma-solitary nonfunctioning thyroid nodule Malignant: Primary Metastatic

18. Nodules common, whereas cancer relatively uncommon Higher in women (1.2:1  4.3:1) Estimated 5-15% of nodules are cancerous Although cancer more common in women, a nodule in a man is more likely to be cancer

19. Workup of a solitary thyroid nodule

20. Laboratory Studies Most patients with thyroid nodules are euthyroid Blood TSH level Serum Tg levels Serum calcitonin levels RET oncogene mutations 24-hour (urine) for vanillylmandelic acid (VMA), metanephrine , and catecholamine

21. Imaging Ultrasound is helpful for: detecting nonpalpable thyroid nodules differentiating solid from cystic nodules identifying adjacent lymphadenopathy Follow up of size of suspected benign nodules CT and MRI are unnecessary in the routine evaluation of thyroid tumors , except for large, fixed, or substernal lesions. Scanning the thyroid with 123 I or 99m Tc for evaluating patients for "hot" or autonomous thyroid nodules

22. Management Malignant tumors are treated by thyroidectomy Simple thyroid cysts: aspiration If the cyst persists after three attempts at aspiration, unilateral thyroid lobectomy is recommended. Lobectomy is also recommended for: cysts greater than 4 cm in diameter complex cysts with solid and cystic components

23. Management If a colloid nodule is diagnosed by FNA biopsy, patients should still be observed with serial ultrasound and Tg measurements. l-thyroxine in doses sufficient to maintain a serum TSH level between 0.1 and 1.0 U/mL may also be administered. Thyroidectomy should be performed if: Nodule enlarges on TSH suppression, compressive symptoms Cosmetic reasons H/o previous irradiation of the thyroid gland Family history of thyroid cancer