TOPIC metal hydride pharmacy .pptx

TOPIC metal hydride pharmacy TOPIC metal hydride pharmacy TOPIC metal hydride pharmacy TOPIC metal hydride pharmacy TOPIC metal hydride pharmacy TOPIC metal hydride pharmacy TOPIC metal hydride pharmacy TOPIC metal hydride pharmacy TOPIC metal hydride pharmacy TOPIC metal hydride pharmacy

1. TOPIC :- Metal Hydride Reaction (NaBH4)(LiAlH4)

2. Metal hydride reaction- .Aldehydes and ketones are converted to primary and secondary alcohols by metallic hydrides such as lithium aluminum hydride (LiAlH 4 ) and sodium borohydride (NaBH 4 ). Such a reaction is called metal hydride reduction reaction.

3. Reactions And Reagents 1. Reduction of Aldehydes and Ketones Reagents: LiAlH ₄ (Lithium aluminium hydride) – very strong reducing agent NaBH ₄ (Sodium borohydride ) – milder than LiAlH ₄ * General Reaction: Aldehyde or Ketone + Metal Hydride → Alcohol Example:- RCHO + NaBH ₄ → RCH₂OH RCOR ' + LiAlH ₄ → RCH(OH)R

4. Reaction And Reagents 2 . Reduction of Carboxylic Acid And Esters Reagent : L iAlH ₄ ( NaBH ₄ is not strong enough ) General Reaction: RCOOH or RCOOR' + LiAlH ₄ → RCH₂OH