Transmissible Venereal Tumors in dogs.pptx

no comments

1. Transmissible Venereal Tumour Submitted by Arya U G 16-BVM-111

2. Signalment Species : Canine Breed : Golden Retriever Sex: Female Age : 5 Years Body Weight : 35 kg

3. Anamnesis Owners Complaint: Reported that animal having pink coloured mass on vulva. Present History: Owner observed bleeding from the mass and constant licking of that area. Past History: The dog was crossed 2 months back , but animal was not conceived.

4. Physiological Parameters Temperature : 101.6˚F Mucous membrane : Pale roseate Peripheral Lymph nodes : Palpable

5. Clinical Examination Animal is active and alert . General body condition : Good Haemorrhagic cauliflower like mass on the vulval lips.

6. Cytology Clinical materials : Impression smear and vaginal swab Round cells with well defined border Large nucleous to cytoplasm ratio Cytoplasmic vacuolation Haematology : no abnormalities could be detected

7. Treatment Inj. Vincrystine @0.025mg/kg slow iv ( after mixing with NS ) Inj. Pantopazole @1mg/kg iv followed by Tab Pantoprazole @1mg/kg orally for 7 days Review after 1 week Prognosis : Good

8. Transmissible Venereal Tumour Infectious Sarcoma, Venereal Granuloma, Stickers Sarcoma, Canine Condyloma, Transmissible Lymphosarcoma

9. Etiopathology Allogenic cellular transplant, not neoplasticaly transformed canine cells. Only naturally transmissible canine tumour Suspected reticuloendothelial orgin

10. Host Foxes and dogs Young, sexually active dogs Age : 4.1 to 4.9 (1 to 11 years) No breed predisposition

11. Transmission By seeding of exfoliated tumour cells from donor to susceptible hosts Mode of transmission : Coitus, licking More rapid growth and metastasis in young and immunocompromised animals Spontaneous regression can occur due to immune response Recovered animals are immune to further invasion of TVT cells Metastasis may occur in < 5% cases

12. Parts affected Males : Caudal part of penis, from crura to bulbus glandis , area of glans penis , Occasionally on prepuce. Females : Posterior part of vagina, Junction of vestibule and vulva, Surrounding the urethral orifice, vulva. Mouth, nose.

13. Symptoms and Lesions Solitary/multiple nodules Cauliflower like Pedunculated Multilobulated Foetid serosanguineous discharge Preputial swelling at the base of penis Excess licking Urethral blockage and urine retension Nose – Epistaxis Mouth – Halitosis Eyes – Epiphora Subsequent maggot infestation

14. Diagnosis History Cytology : Impression Smears/ Swabs/ Fine needle aspirates Stain : Giemsa, Field’s ,Leishman DDX : Mast cell tumour , Vaginal hyperplasia, Canine lymphoma, Fibroma

15. Treatment Chemotherapy Surgery Radiation Immunotherapy Cryotherapy

16. Chemotherapy Single drug / combination

17. Vincristine Sulphate Vinca Alkaloid Interferes with microtubule assembly Retard the formation of spindle at metaphase stage of mitosis Dose : 0.025mg/kg strict iv weekly once or 0.5mg/square metre Complete remission after ~3.3 treatments (2 to 7)

18. Side effects Extravasation GI disturbances: Nausea, vomiting Muscle pain Myelosuppression

19. Doxorubicin Anthracycline antibiotic Binds to DNA , Inhibit nucleic acid synthesis ,prevents topoisomerase II function Dose : 30 mg/sq m iv every 3weeks until remission Expensive

20. Combination Vincrystine Sulphate (0.025 mg/kg orally daily) + Cyclophosphamide ( 1mg/kg orally daily) + Methotrexate (0.3-0.5mg/kg iv weekly) Tumour regression usually occurs in 10.2 days