Treatment of h.pylori

Different regimen in treatment of H.pylori

1. H.Pylori Treatment Abdallah Sabry Elgameel 631

2. Recurrence….. 20% Eradication….. 80%

3. Strategy of treatment Selectivity Spectrum Duration Dose Clarithromycin Amoxicillin metronidazole Tetracycline Levofloxacin Bacteriostatic ?????? Bacteriostatic Bacter icidal Bacter icidal 14 days 500 mg ...2T/D 500 mg ...2T/D 500 mg ... 4 T/D 500 mg ...2T/D 1000 mg ..2T/D

4. Bismuth subcitrate potassium Direct antimicrobial action Effective against H.Pylori 525 mg …..4T/D Strategy of treatment Proton pump inhibitor Omeprazole…..20mg....20T/D Lansoprazole….30mg…20T/D

5. Regimen PPI Clarithromycin Clarithromycin-triple therapy Bismuth-quadruple therapy PPI Bismuth Tetracycline metronidazole

6. Regimen Levofloxacin therapy PPI Levofloxacin Amoxicillin Antimicrobial susceptibility test

7. PPI Bismuth Tetracycline metronidazole Bismuth-quadruple therapy Regimen Non -Bismuth-quadruple therapy PPI Clarithromycin Amoxicillin metronidazole

8. Regimen Sequential therapy Amoxicillin PPI Clarithromycin metronidazole PPI

9. Regimen Levofloxacin therapy PPI Levofloxacin Amoxicillin Antimicrobial susceptibility test

10. Thank you