Tree-man disease (Epidermodysplasia Verruciformis)

Epidermodysplasia Verruciformis colloquially known as treeman disease is one of the rarest genetic disease.
*its images seems to be horrifying however it isa non contagious disease means that it does not spread simply by touching the person which have it.
This disease cannot be cured however it can be removed surgically but it grows again.

1. Epidermodysplasia Verruciformis By: Ashish Kumar

2. Submitted By :- Ashish Kumar Class: XII B Roll no. 28   Under the Guidance of :- Mrs. C. Thapa PGT (biology) Topic :- Epidermodysplasia Verruciformis (Tree-man disease)   Kendriya Vidyalaya No.1 Pathankot. INVESTIGATORY PROJECT WORK (BIOLOGY)

3. “There are times when silence speaks so much more loudly than words of praise to only as good as belittle a person, whose words do not express, but only put a veneer over true feelings, which are gratitude at this point of time”. I would like to express our sincere gratitude to our biology teacher Mrs. Chandra Thapa for his vital support, guidance and encouragement- without which this project would have come forth. I also thanks to my parents for their motivation & support. I must thanks to my classmates for their timely help & support for compilation of this project.   This project was an amiable as well as inspiring assignment to me for achieving the success.   Ashish Kumar Roll no. 28 ACKNOWLEDGEMENT

4.   This is to certify that Ashish Kumar student of class XII th - B Kendriya Vidyalaya No.1 AFS Pathankot has completed the project titled :-“ Epidermodysplasia verruciformis ” (colloquially known as tree man disease) during the academic year 2016-2017 towards partial fulfillment of credit for the Biology practical evaluation of CBSE 2016-2017, under the supervision of Mrs. Chandra Thapa.   Teacher In-charge Examiner Principal CERTIFICATE

5. 1) Acknowledgement. . . . . . . . . . . . . . . . . . . 2) Certificate. . . . . . . . . . . . . . . . . . . . . . . . 3) Scientific description. . . . . . . . . . . . . . . . . 4) Symptoms. . . . . . . . . . . . . . . . . . . . . . . . . 5) Causes. . . . . . . . . . . . . . . . . . . . . . . . . . . 6) Cures. . . . . . . . . . . . . . . . . . . . . . . . . . . 7) Facts. . . . . . . . . . . . . . . . . . . . . . . . . . . . 8) BIBLIOGRAPHY. . . . . . . . . . . . . . . . . . . . . .   CONTENTS

6. Scientific Description Epidermodysplasia Verruciformis, or EV, (colloquially known as tree man illness) is a rare skin disorder that exposes patients to the human papillomavirus (HPV) and cutaneous squamous cell carcinomas. The disease is linked to chronic infection of HPV. Skin eruptions of flat-to-papillomatous, wartlike lesions and reddish-brown pigmented plaques on the trunk, the hands, the upper and lower extremities, and the face. Malignant skin tumors (carcinomas), usually squamous cell carcinoma, develop on the patient with this disease. This disease causes warts and horns to form on the hands, feet, and face. They form due to exposure to the human papillomavirus.(HPV)

7. Symptoms Thick visible warts all over the body as well as on the inside of the skin.  Flattened warty skin lesions. The skin becomes thick and hardened and as old skin dies new skin is  created. Increased vulnerability to human papillomaviruses of the skin. The hands and feet, the extremities, are enlarged and it is difficult to use them. Skin looks like tree bark  or tree roots, hence the name Tree-Man Disease.

8. Causes Doctors have linked genetics to Epidermodysplasia Verruciformis. Although this disease is rare, doctors say the person inherits the disease from their parents or it “runs” in the family. Another major cause of this disease is a horrible immune system. This disease is found in countries that don’t have the best of medical care. Is It Contagious? It is important to understand that though images are quite shocking, but the disease is not contagious. Doctors check these people and their warts without an issue, and they have already confirmed that no one can get infected just by touching the person who has it.

9. Mutation is the process by which an organism’s DNA sequence is altered. In the case of the sufferers of Tree Man Syndrome, mutation occurs in their EVER1 and EVER2 genes on chromosome 17 which are responsible for regulating the circulation of Zinc in the nucleus of cells. These genes prevent the entree of viral proteins to cellular zinc stores resulting to their restricted growth. These zinc stores are needed for the body’s immune system to function properly. Hence, those affected by the ailment lack the ability to protect themselves from certain bacteria or viruses which, in the case of tree man syndrome, are Human Papillomavirus

10. Cure for EV There is no cure for Epidermodysplasia Verruciformis however the warts can be surgically removed, but they do grow back. Try chemotherapy and other drugs prescribed by a doctor one case was treated with a combination of acitretin and interferon alfa-2a . Direct radiation therapy to control the growth has led to cancer in one patient. Scientists and doctors such as Dr. Anthony Gaspari , an American dermatologist from the University of Maryland, are currently studying three cases of Tree-Man Disease in the hope of finding a genetic  link that will lead to a cure of this disease.

11. Worst Case Scenario The worst case scenario for EV is that you are not able to use your hands or feet. Depending on how bad the case is the hands and feet can become very heavy and uncomfortable due to the warts. In Treeman’s case, he will need two surgeries every year to keep them from growing big again. Before Surgery After Surgery

12. FACTS It is one of the rarest genetic disease on earth. This disease can be linked to the mapping of chromosome 17. EV is usually diagnosed when the patient is between the ages of 1 and 20. EV is more commonly found in countries with little medical treatment available. This disease is not contagious means that this disease do not spread simply by touching. It can be caused by a common sexually transmitted wart virus infection.

13. Sources http:// emedicine.medscape.com/article/1131981-overview http:// www.rightdiagnosis.com/medical/epidermodysplasia_verruciformis.htm http:// www.ncbi.nlm.nih.gov/pubmed/11464195 Information was also pulled from the documentary Tree-man: Search for the Cure that I found on youtube