Type iv hypersensitivity reaction

super short presentationonly type IV hypersensitivity reaction

1. Type-IV Hypersensitivity Reaction Dr. Arushi Agarwal JR-1 Pathology

2. Hypersensitivity Reaction Injurious immune response Exaggerated/inappropriate state of normal immune response with onset of adverse effects on the body

3. Types Immediate type Type I : Anaphylactic Type II : Cytotoxic Type III : Immune Complex Mediated Delayed Type Type IV : Cell-Mediated

4. Type IV Hypersensitivity Cell-mediated immune disorders Caused by: Cytokines produced by CD4+T cells Cell killing by CD8+ T cells

5. Activation of CD4+T cells CD4+T cells Recognise peptides displayed by dendritic cells Secrete IL-2 Proliferation of antigen-responsive T cells

6. Differentiation of antigen responsive T-cells Antigen presenting cells T H 17 SUBSET (Dominated by neutrophils) T H 1 SUBSET (Dominated by activated macrophages) IL-12 IL-2, IL-3, IL-23

7. Examples: Tuberculin reactions Granulomatous inflammation Contact dermatitis Rheumatoid arthritis Multiple sclerosis Inflammatory Bowel Disease Psoriasis

8. T-cell mediated killing of targets involves : Perforins and granzymes Activation of apoptosis. Examples: Type 1 Diabetes Mellitus

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