urolift ppt , Minimally invasive treatment for prostate enlargement.pptx

minimally invasive treatment for enlarged prostate , Urolift . best for young sexually active male who wants to preserve ejaculatory function

1. Recent advances in management of Enlarged prostate - UROLIFT DR Y P SINGH RANA DIRECTOR - UROLOGY URO ONCOLOGY AND RENAL TRANSPLANT BLK MAX HOSPITAL

2. MODERN UROLOGY = TECHNOLOGY .. lasers/mini endoscopes/ Robots

3. Increasing age incidence

4. Bph An anatomic entity producing Bladder Outlet obstruction

5. MC-XXXXXX 1 The UroLift System Vision MAC01130-04 Rev A MCI-2022-0304

6. A g e n da 1 Emerging trends in BPH What’s new with the UroLift System and procedure Local patient trends 2 3

7. International Prostatic Symptoms Score Questions Score 1-5 1 frequency 2 urgency 3 Weak stream 4 Incomplete 
void 5 hesitancy 6 Straining to
void 7 nocturia 8 Quality of 
life

8. Top 10 Reasons for Visits to Urologists 1 1 200 Annual Visits per Urologist 3 4 BPH Surgery Follow Up Prostate Cancer Penis Disorder, Other Specific Exam, Other Urinary Tract Infection Abnormal Blood Chemistry Kidney Stones Hematuria Bladder Function Disorder 1. IMS Health NDTI Urology Specialty Profile, July 2012 - June 2013

9. 1 in 3 men are satisfied with the effectiveness of their medication 1 Men are Bothered by LUTS, Even When on Rx Therapy 1. Prostate Research Study, Harris Interactive Group 2007 of men age > 50 seeing a urologist are interested in an alternative to me d i c ati o n f or BP H 1 65%

10. Expert Opinion 1 A. 0-5% B. 6-10% C. 11-20% 100 Urologists and Practice Staff were asked: What percentage of your practice’s BPH patients do you think should receive advanced BPH therapies? # Respondents 3 out of 5 of those surveyed thought ≥ 20% of BPH patients should receive advanced treatment 1. UroGPO Conference Survey, November 30, 2018

11. BPH Can Be Frustrating for Both Urologists and Patients 2.6% 1 Patient # is based on men 40-80 y/o and 43% of these patients are bothered by LUTS and 26% have seen a GP. Used 0.711 as Xchange rate for AUD to USD NeoTract OUS Model, ABS Population data, Medicare data and PBS pricing Business Wire, accessed Nov 2018 at https://www.businesswire.com/news/home/20180813005276/en/Global-Benign-Prostatic-Hyperplasia-Devices- Market-2018-2022 Only of BPH patients elect for intervention

12. Urologists and Patients Have Different Points of View Data on file: VOC Tracking Study 2019, n = 153 urologists (US) Data on file: Mens Health Survey 2018, n = 203 of urologists report discussing BPH procedures with moderate to severe BPH patients early after their BPH diagnosis 1 88% 23% of patients said their doctor suggested minimally invasive procedures as an alternative to medication 2

13. SAFE AND EFFECTIVE Benefits and side effects of BPH medications: comparison of outcomes at 1-2 years 6. AUA BPH Guidelines 2003, 2010; 7. Jan Teper, Cent Eur J Urol 2011; 8. Traish, J Sex Med 2015 9. Marihart al. Rev Urol 2005

14. Significant improvement without the significant permanent downsides of laser/TURP Indicated for the treatment of symptoms of an enlarged prostate up to 100 cc in men 50 years or older. As with any medical procedure, individual results may vary. Most common side effects are temporary and include hematuria, dysuria, micturition urgency, pelvic pain, and urge incontinence. 1 Rare side effects, including bleeding and infection, may lead to serious outcomes and may require intervention. Consult the Instructions for Use (IFU) for more information. There was no occurrence of new onset, sustained erectileor ejaculatory function in the L.I.F.T. study. 1. Roehrborn, J Urol 2013; 2. Roehrborn, Urol Practice 2015; 3. Sonksen, Eur Urol 2015; 4. Cindolo et al. Int Urol Nephrol 2017; 5. Noordhoff et al. Neurourol Urodyn 2019; 6. AUA BPH Guidelines 2003, 2010 SAFE AND EFFECTIVE

15. Men’s Perceptions of Importance When Considering a Minimally Invasive Procedure for BPH No Post Op Catheter Rapid Relief Rapid Recovery Minimal Downtime Minimal Procedure Discomfort Preserves Sexual Function Office Procedure Local Anesthe s ia 10 = Most Important 7.7 7.0 6.9 6.1 6.0 5.8 4.5 3.9 Source: NeoTract-sponsored Men’s Health Survey, November 2018. n = 1,000 men (88% of respondents were over age 45 years of age). Respondents compared items to each other by placing them in order of importance.

16. “Since many men discontinue medical therapy, yet proportionately few seek surgery, there is a large clinical need for an effective treatment that is less invasive than surgery. With this treatment class, perhaps a significant portion of men with BOO who have stopped medical therapy can be treated prior to impending bladder dysfunction.” From healthy bladder to permanent damage AUA BPH Guidelines Recognise the Need for Intervention Healthy Bladder Bladder Worsens Permanently Damaged

17. Intervention avoidance Proven safe Proven effective Straight-forward to implement and use Broad reimbursement coverage Rx

18. The UroLift System has Extensive Clinical Data Support Eure et al J Endourol 2019 Roerhborn et al. Can J Urol 2017 1 Five year durability of implant 2 ​ Proven in the real world 1​ Consistent results across studies   published

19. Stable Response The combination of the mechanical effect of pulling back the prostate and tissue atrophy, together, sustain results. Coronal full-face transverse canine prostate section showing localized compression in implant zone. Note deformation on capsular side due to lack of fibromuscular capsule in canine. (PPR00024 App 2 Fig 13). Moderate lobular atrophy and mild chronic infla m m a t i on in t i ss ue s urrou nd i n g i m plan t . (PPR00024 App 2 Fig 17). Lon g - T e r m 1 Durability Pre-Clinical Animal Study Explains Durability 1. Roerborn et al Can J Urol 2017 Ischemia and Atrophy Compression

20. Treating Obstructive Median Lobes with The UroLift System

21. Now, You Can Offer Rapid Symptom Relief and Recovery To Even More Of Your BPH Patients ✓ ✓ ✓ ✓ ✓

22. AUA BPH GUIDELINE HIGHLIGHTS: Urologists “should consider” PUL…. Patients “ should be made aware that surgical treatment can cause ejaculatory dysfunction (EjD) and may worsen ED .” “In men so concerned about new onset of ED and/or EjD, PUL likely does not pose additional risk.” The UroLift System Procedure: Part of the Standard of Care

23. Thank you for your attention After UROLIFT Flow of urine

24. Questions? Any Questions? Teleflex, the Teleflex logo, and Urolift are trademarks or registered trademarks of Teleflex Incorporated or its affiliates, in the U.S. and/or other countries. © 2022 Teleflex Incorporated. All rights reserved. MCI-2022-0304 · 04 22 Information in this material is not a substitute for the product Instructions for Use. Please see the Instructions for Use for a complete listing of the indications, contraindications, warnings and precautions. The products in this document may not be available in all countries. Please contact your local representative.

25. Thank You Thank You Teleflex, the Teleflex logo, and Urolift are trademarks or registered trademarks of Teleflex Incorporated or its affiliates, in the U.S. and/or other countries. © 2022 Teleflex Incorporated. All rights reserved. MCI-2022-0304 · 04 22