vatsanabha.pptx

ppt

1. वत्सनाभ

2. महाविष हालाहलः कालकूटः श्रृंगकश्च प्रदीपनः। सौराष्ट्रिको ब्रह्मपुत्रो हारिद्रः सक्तुकस्तथा।। वत्सनाभ इति ज्ञेया विषभेद अमी नव। (र.त.२४/७)

3. Contents

4. वत्सनाभ Botanical name : ACONITUM FEROX FAMILY : RANUNCULACEAE Vernacular name : English : Monkshood Kannada: Vatsanabhi Hindi : Bachnag, Mita vish Malyalam : Valsanabhi

5. निरुक्ति : “वत्सस्य नाभिरिव वत्सनाभः।” पर्याय : अमृत उग्रविष महौषधव गरल स्थावराद्यम् वत्सनाग

6. General description (Morphology) Type : Perennial herb reaching upto 1m tall Root : (5-10cm length) Dry root is more or less conical with tapering end. Surface presents scars or bases of broken rootlets and is usually arched and shriveled with longitudinal wrinkles. Dark brown externally, whitish and starchy internally.

7. Stem : Erect, covered with short spreading yellow hairs. Leaf : Scattered, glabrus,blade orbicular cordate to reniform in outline. Palmately 5 lobed Inflorescence : Dense racemose bearing blue flowers on both sides. Fruits : Capsule, tomentose.

8. Chemical composition Aconitine Pseudo aconitine Aconine Alkaloids

9. Aconite Pseudo aconite

10. Aconite binds with high affinity Aconite poisoning mechanism

11. Purification Nimajjana in gomutra for 3 days Swedana using ajadugda for 1 yama kaala

12. Fatal dose: 1 - 2g of root 4 – 6mg of aconitine Fatal period: 2 – 6 hrs

13. Toxicity L Acute toxicity : burning or tingling sensation of the lips, tongue, mouth, and throat almost immediately after ingestion Subacute toxicity: Nausea, vomiting, dizziness, fatigue, blurring of vision .

14. Signs and symptoms GIT - Bitter & sweet taste in mouth, - Intensive burning & tingling on lips, mouth and . throat. - Salivation, nausea, vomiting & Pain abdomen CVS - HPT, Chest pain, Palpitation - Pulse slow, feeble & irregular CNS - Vertigo, restlessnessgiddiness RS - Respiration slow & shallow Others - Pupils alternatively contract and dilate.(Hippers sign). Temp subnormal, skin cold

15. Treatment There is no specific antidote for aconitin and treatment is supportive Gastric lavage with warm water, milk, tannic acid Multiple dose of activated charcoal Atropine 0.5 – 1 mg to treat bradycardia Symptomatic treatment

16. Postmortem Appearance Usually unidentified Fragments of root in stomach contents Frothy mucous in tracheobronchial tree Odour of chloroform in stomach Necrosis of myocardium

17. Medico – legal Importance It is an ideal homicidal poison as it is cheap easily available , colour can be disguised by mixing it with sweets or by giving it with betel leaf Accidental poison is common Sometimes used as abortifacient, cattle poisoning or arrow poisoning

18. औषध योग : आनंद भैरवि रस संजीवनी वटि त्रिभुवन कीर्ति रस मृत्युंजय रस

19. A 27 years old, male patient presented to the emergency room on 5 th  March 2020, at 5 pm with complains of dizziness and vomiting for past one hour. He gave history of consumption of herbal remedy with honey from folk medicine. The content of this herbal remedy was not known. After an hour of using it, he developed tingling sensation in the tongue and blurry vision and perioral numbness. Soon he started feeling dizziness. The patient also complained of vomiting and diarrhea. Vomiting more than 8 episodes and had mainly undigested food while he had 3 episodes of diarrhea.

20. The patient was a known case of anxiety disorder and was on fluoxetine 20 mg once daily and olanzapine 2.5 mg once daily. The patient didn’t have any past history of allergy to food or drug. Vaccination history was complete, according to Saudi Vaccination schedule. There was no history of recent blood transfusion. No any significant past surgical history. He is living in a family house with an average income. He is on regular family diet.

21. After seeing these symptoms and signs, we suspected a poisoning case. After collecting and amount of samples brought to emergency department and send later to toxicology lab, the examination showed aconite substance along with other