Water Content Vs. Loss On Drying Of Drug In Pharma Company Part-2

Water Content of Drug?
Impact Of Water Content Of Drug.
Methods Of Determining Water Content Of Drug.
Formula for Water Content Determination.
Calculation With Lab Practical Demo.
Loss On Drying of Drug?
Impact Of LOD Of Drug.
Formula of LOD Determination.
Calculation With Lab Practical Demo.
Basic Difference.

1. Water Content Vs. Loss On Drying Of Drug In Pharma Company Part-2

2. Contents: Water Content of Drug? Impact Of Water Content Of Drug. Methods Of Determining Water Content Of Drug. Formula for Water Content Determination. Calculation With Lab Practical Demo. Loss On Drying of Drug? Impact Of LOD Of Drug. Formula of LOD Determination. Calculation With Lab Practical Demo. Basic Difference. All Copyrights Reserved At API Pharmaprenuer Tech

3. Loss on drying Of drug: Loss on drying is the loss of weight expressed as percentage w/w resulting from water and volatile matter of any kind that can be driven off under specified conditions. Loss on drying test is designed to measure the amount of water and volatile matter in a sample when the sample is dried under specific condition The test is carried out on a well-mixed sample of the substance. LOD is performed as in-process testing for wet cake samples of drug from various stages. LOD will always be more than water content because LOD result gives water content, solvent in substance.  Although Water content gives only amout of water present. All Copyrights Reserved At API Pharmaprenuer Tech

4. LOD impact: Intermediate & API: LOD determination error might impact the qty of drug | intermediate on dry basis and thus impact the reaction mechanism and ultimately to ending results in the form of quality and quantity of outcomes as next intermediate or API . Clogging or caking in process equipment . Microbial Growth on Finished API | Intermediate. All Copyrights Reserved At API Pharmaprenuer Tech

5. LOD Determination methods: Thermogravimetry Method Oven drying method | LOD moisture meter method Near Infrared moisture meter method . All Copyrights Reserved At API Pharmaprenuer Tech

6. Oven Drying Method (LOD): Formula for LOD determination: All Copyrights Reserved At API Pharmaprenuer Tech %LOD = Initial Sample Weight – Wt. of Dried Material X 100 Total Weight of Drug Taken

7. Calculation With Lab. Demo: So to understand the LOD % in Wet substance, Refer the lab demo shown in my video topic water content. Suppose : Net Weight of Wet Sample taken : 15 gm Net Weight of Sample after Drying in Oven: 10.78 gm All Copyrights Reserved At API Pharmaprenuer Tech

8. Calculation With Lab. Demo: Calculation Continue…. By Putting all obtained values in below formula: It means that wet cake has 28.1% water & other volatile substance and 71.9 % of actual weight of material on dry basis. All Copyrights Reserved At API Pharmaprenuer Tech %LOD = 15 – 10.78 X 100 15 %LOD = 4.22 X 100 15 %LOD = 28.1%

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