Wet granulation

Description about Wet Granulation:

1. Wet Granulation:

2. Wet Granulation: Method in which the powder particles mix can be done by the use of granulating liquid. Volatile solvent is used as a granulating liquid. GRANULATING LIQUIDS: Ethanol. Isopropanol & water (used individually or in the combination).

3. Steps involve in Wet granulation Mingling of Excipients & Drugs. Mixing of powder with binder solution. Granular sieving of wet mixture. Drying of soggy granules. Sifting of dry granules.

4. Methods involve in Wet granulation: 1) Shear Granulator: dry powder mixing has to be accomplished in a single primary process using diverse mixing equipment’s for powders. replaced by high speed granulators. 2) Fluid bed granulation: particles of powder are fluidized in an air stream. the granulating liquid is added into the powder bed.

5. Methods involve in Wet granulation: 3) Spheronization (Extrusion): yield multi particulates by the application of measured release of drug. produces spheres or pellets loaded with drug 4) High Speed granulator: is used widely for medicinal granulation. established from old-style environmental mixers to accelerate the procedure to decrease the quantity of equipment’s.

6. Advantages of wet granulation: P roduction of granules Shows high compression of particles. Hardness, disintegration, dissolution, and moisture, correlation in compacted tablets is prepared by this Process Disadvantages of wet granulation: High energy utilization Less stable with water