What is Monocytosis, By Doctor Rifat

This is an explanation of Monocytosis by Dr.Rifat (Associate Professor Pathology M.D.)

1. Monocytosis By Dr. Rifat Qureishi Usmani

2. What is MONOCYTOSIS ? Monocytosis is an increase in the number of monocytes circulating in the blood. Monocytes are white blood cells that give rise to macrophages and dendritic cells in the immune system. In humans, monocytosis occurs when there is a sustained rise in monocyte counts greater than 500cells/ µL .

3. Monocytosis Causes • Infections: tuberculosis, brucellosis, listeriosis, subacute bacterial endocarditis, syphilis, and other viral infections and many protozoal and  rickettsial  infections (e.g. kala azar, malaria, Rocky Mountain spotted fever). • Blood and immune causes: chronic neutropenia and myeloproliferative disorders. • Autoimmune diseases and vasculitis: systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease. • Malignancies: Hodgkin's disease and certain  leukaemias , such as chronic myelomonocytic leukaemia  (CMML) and monocytic leukemia. • Recovery phase of neutropenia or an acute infection. • Obesity (cf. Nagareddy et al. (2014), Cell Metabolism, Vol. 19, pp 821–835) • Miscellaneous causes: sarcoidosis and lipid storage disease.

4. Normal Monocyte

5. Monocytosis

6. Thankyou Monocytosis Prepared by Dr. Rifat Usmani