Wittig reagent

Triphenyl phosphine alkylidenes

1. Wittig Reagent Presented By: Gandham Malasree M Pharmacy I year I sem Regd no: 620209502002 Dept of Pharmaceutical Chemistry AU COLLEGE OF PHARMACEUTICAL SCIENCES, VISAKHAPATNAM

2. Wittig reagent • Triphenyl phosphine alkylidenes Alternative names • Triphenylphosphoniumylide • Alkylidenephosphorane wittig reagent R = -CH 2 , -C 2 H 5 , -C 4 H 9

3. Forms Of Wittig Reagent

4. General Preparation Of Wittig Reagent

5. MECHANISM 1) SN2 reaction

6. 2) Deprotonation

7. APPLICATIONS 1.Incorporation of exocyclic methylene group

8. 2.Synthesis Of Indole

9. 3.Preparation of alpha, beta unsaturated esters

10. 4.Synthesis of dienes

11. 5.Preparation of olefins

12. 6.Synthesis of aldehydes

13. 7.Synthesis Of Natural Compounds Synthesis of squalene

14. Synthesis of beta carotene

15. Thank you