Working principle of compression machine

The basic principle behind the tablet compression machine is hydraulic pressure. This pressure is transmitted unreduced through the static fluid. Any externally applied pressure is transmitted via static fluid to all the directions in the same proportion. It also makes it possible to multiply the force as needed.

1. Working principle of compression machine Presented By Prashik Humane Department of Pharmaceutical Sciences, RTMNU, Nagpur 1

2. Contents Introduction Compression facilities Different parts of compression machine Mechanism of compression cycle Additional machine line Critical process parameter In-process testing 2

3. Introduction Compression- Compression is a process of applying pressure to the powder material for the reduction of bulk volume to give a solid matrix. It is a process by which granules are compressed into the core tablet form. The manufacturing of solid dossage form such as a complex multistage process under which the starting material change there physical characteristics a number of time before the final dossage form is produced. Need of Compression- To form the unit dossage form For better stability as compare to other dossage form Cost effective Patient compliance 3

4. Compression facility 4

5. Different change parts Hopper Upper and lover cam track s Dies and punches Feeders Tail over die and scraper blade Pressure role Take off plate filling cam and ejection cam Dust cap 5

6. Mechanism of compression Filling Compression Ejection 6

7. Common Stages occurring During Compression 7

8. In-process testing Weight variation test Thickness Hardness diameter/ length/ width Disintegration test Friability 8

9. Additional machine line De-duster Machine Metal Detector 9

10. Critical process parameter Filling depth Punch separation Pre-compression force Main compression force Turret RPM Tablet per minutes 10

11. Thank you 11