World Digestive Health Day 2024 and .pptx

“World digestive Health Day advocates the necessity of a healthy diet in the promotion of optimal gastrointestinal function and microbiome health. The goal is to promote a healthy lifestyle and improve understanding of the importance of a healthy gastrointestinal (GI) tract”
The GI tract is an essential organ that provides nutrients, enhances the immune response, and houses the intestinal microbiota. Comprehending the normal functions of the GI tract and diet can help identify when to seek GI care for symptoms

1. Insights for Health Care Physicians on World Digestive Health Day 2024.

2. " Your Digestive Health: A Healthy Gut From the Start ” Theme: “World digestive Healt h Day advocates the necessity of a healthy diet in the promotion of optimal gastrointestinal function and microbiome health . The goal is to promote a healthy lifestyle and improve understanding of the importance of a healthy gastrointestinal (GI) tract ” The GI tract is an essential organ that provides nutrients, enhances the immune response, and houses the intestinal microbiota. Comprehending the normal functions of the GI tract and diet can help identify when to seek GI care for symptoms. 

3. Dietary patterns and environmental factors influence the composition of the gut microbiota in real-time. The fermentation of dietary fiber by diverse populations of intestinal bacteria produces beneficial short-chain fatty acids, which contribute to lipid regulation and inflammation reduction Healthy diet ( especially high fiber diet ) and lifestyle plays a very important role to maintain healthy gut. Foods that are beneficial for the gut microbiome are called prebiotics; The various prebiotic fruits and vegetable are; - Garlic -Onions - Bananas -Beans - Whole grains (wheat, oat, barley etc) Implications for Diet and Disease:

4. Understanding the Microbiome The concept of a “core” microbiome, originally considered as a common set of microbes required by the host for maintenance of health, has given way to pursuit of core functions for the microbiome, but these vary with context, and multiple definitions of what constitutes a core microbiome have emerged with no consensus.

5. The Healthy Microbiome—What Is the Definition of a Healthy Gut Microbiome? , Fergus Shanahan, Tarini S. Ghosh, Paul W. O’Toole, Gastroenterology, Volume 160, Issue 2,

6. Functional Redundancy The gut microbiome exhibits extreme diversity in composition and temporal variability within individuals. However, its metabolic function is relatively less diverse and highly conserved across individuals . This suggests that a functional definition based on metabolomic and metaproteomic analysis may be more effective than taxonomy in distinguishing a normal microbiome from an abnormal one. Additionally, the metabolic activity of the gut microbiome is interconnected, forming a complex metabolic web rather than a series of isolated pathways. .

7. Lessons From Outliers An example of this is seen in the Irish Travelers, an ethnically distinct subpopulation in Ireland. Despite living in a socioeconomically developed country , the Irish Travelers have a distinct microbiome resembling that of non-industrialized societies , different from the industrialized microbiome of the settled Irish population. The distinctive microbiomes of minorities , like those of the Irish Travelers, have important implications for translating microbiome science . They challenge the accuracy of restrictive definitions of what constitutes a healthy microbiome in a pluralistic society.

8. Strains Matter Recent advancements in microbiome research have revealed the importance of strain-level heterogeneity within gut species. Traditional techniques had limitations in detecting strain-level variations and functional capacities. However, with the decreasing cost of shotgun metagenomic sequencing and improved software, different strains of the same species can now be distinguished within individuals .

9. The human microbiome interacts with genes, environment, and time, contributing to non-communicable chronic diseases (NCCDs). While the composition of the microbiome remains relatively stable in health, its metabolic activity varies. Factors such as physiological aging, immune senescence, diseases, and medications can create instability in microbiome composition . Identifying microbial profiles in middle age that confer an increased risk of diseases in later life, such as colorectal cancer, presents an opportunity for prevention. The Changing Nature of the Microbiome and Its Clinical Implications

10. Migration and disease risk related to age and change in microbiome. Migration from non industrialized (low-risk) to industrialized (high-risk) regions is associated with an increased risk of developing immune-mediated, noncommunicable chronic diseases (NCCDs) such as Crohn’s disease, asthma, type 1 diabetes, or multiple sclerosis. The risk is dependent on the age at the time of migration and highest in those migrating in early childhood when the microbiome is being assembled and when the microbiome influence on the maturation of the immune system is greatest. Migration is also associated with a progressive shift in microbiome profile toward that of an industrialized country.

11. Future Directions The future of microbiome science focuses on addressing knowledge gaps, such as the mycobiome and virome , and improving communication of research findings to the public. Advances in microbiome medicine will reshape the field of human nutrition, with the microbiota playing a key role in transducing nutrient signals and offering therapeutic implications for conditions like under-nutrition, obesity, and frailty.

12. SCAN FOR MORE RESOURCES ON GUT MICROBIOME AND DIGESTIVE HEALTH.